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Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects

Meikar, Oliver
Papaioannou, Marilena D
Grey, Corinne
Weier, Manuela
Pralong, François
De Massy, Bernard
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Published in PloS one. 2011, vol. 6, no. 10, e25241
Abstract Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression. In the past decade, small non-coding RNAs have emerged as critical regulators of gene expression both at the transcriptional and post-transcriptional level. DICER1, an RNAse III endonuclease, is essential for the biogenesis of several classes of small RNAs, including microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs), but is also critical for the degradation of toxic transposable elements. In this study, we investigated to which extent DICER1 is required for germ cell development and the progress of spermatogenesis in mice.
Keywords AnimalsApoptosis/geneticsDEAD-box RNA Helicases/deficiency/geneticsDNA Transposable Elements/geneticsGene DeletionGene SilencingInfertility, Male/genetics/pathologyMaleMeiosis/geneticsMiceMice, TransgenicMicroRNAs/geneticsOrgan Size/geneticsRibonuclease III/deficiency/geneticsSeminiferous Tubules/metabolism/pathologySperm CountSpermatocytes/metabolism/pathologySpermatogenesis/geneticsSpermatozoa/metabolism/pathology
PMID: 21998645
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Article (Published version) (2.3 MB) - public document Free access
Research group Mécanismes moléculaires et génétiques du développement sexuel (778)
Swiss National Science Foundation: FNRS
(ISO format)
ROMERO, Yannick et al. Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects. In: PloS one, 2011, vol. 6, n° 10, p. e25241. doi: 10.1371/journal.pone.0025241 https://archive-ouverte.unige.ch/unige:23647

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Deposited on : 2012-10-31

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