Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects

Romero, Yannick; Meikar, Oliver; Papaioannou, Marilena D; Conne, Béatrice; Grey, Corinne; Weier, Manuela; Pralong, François; De Massy, Bernard; Kaessmann, Henrik; Vassalli, Jean-Dominique; Kotaja, Noora; Nef, Serge

doi:10.1371/journal.pone.0025241

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Title		Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects
Authors		Romero, Yannick Meikar, Oliver Papaioannou, Marilena D Conne, Béatrice Grey, Corinne Weier, Manuela Pralong, François De Massy, Bernard Kaessmann, Henrik Vassalli, Jean-Dominique Kotaja, Noora Nef, Serge show all authors [1 - 12]
Published in		PloS one. 2011, vol. 6, no. 10, e25241
Abstract		Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression. In the past decade, small non-coding RNAs have emerged as critical regulators of gene expression both at the transcriptional and post-transcriptional level. DICER1, an RNAse III endonuclease, is essential for the biogenesis of several classes of small RNAs, including microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs), but is also critical for the degradation of toxic transposable elements. In this study, we investigated to which extent DICER1 is required for germ cell development and the progress of spermatogenesis in mice.
Keywords		Animals — Apoptosis/genetics — DEAD-box RNA Helicases/deficiency/genetics — DNA Transposable Elements/genetics — Gene Deletion — Gene Silencing — Infertility, Male/genetics/pathology — Male — Meiosis/genetics — Mice — Mice, Transgenic — MicroRNAs/genetics — Organ Size/genetics — Ribonuclease III/deficiency/genetics — Seminiferous Tubules/metabolism/pathology — Sperm Count — Spermatocytes/metabolism/pathology — Spermatogenesis/genetics — Spermatozoa/metabolism/pathology
Identifiers		DOI: 10.1371/journal.pone.0025241 PMID: 21998645
Full text		Article (Published version) (2.3 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Research group		Mécanismes moléculaires et génétiques du développement sexuel (778)
Project		Swiss National Science Foundation: FNRS
Citation (ISO format)		ROMERO, Yannick et al. Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects. In: PloS one, 2011, vol. 6, n° 10, p. e25241. doi: 10.1371/journal.pone.0025241 https://archive-ouverte.unige.ch/unige:23647