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Scientific article
Open access
English

Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects

Published inPloS one, vol. 6, no. 10, e25241
Publication date2011
Abstract

Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression. In the past decade, small non-coding RNAs have emerged as critical regulators of gene expression both at the transcriptional and post-transcriptional level. DICER1, an RNAse III endonuclease, is essential for the biogenesis of several classes of small RNAs, including microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs), but is also critical for the degradation of toxic transposable elements. In this study, we investigated to which extent DICER1 is required for germ cell development and the progress of spermatogenesis in mice.

Keywords
  • Animals
  • Apoptosis/genetics
  • DEAD-box RNA Helicases/deficiency/genetics
  • DNA Transposable Elements/genetics
  • Gene Deletion
  • Gene Silencing
  • Infertility, Male/genetics/pathology
  • Male
  • Meiosis/genetics
  • Mice
  • Mice, Transgenic
  • MicroRNAs/genetics
  • Organ Size/genetics
  • Ribonuclease III/deficiency/genetics
  • Seminiferous Tubules/metabolism/pathology
  • Sperm Count
  • Spermatocytes/metabolism/pathology
  • Spermatogenesis/genetics
  • Spermatozoa/metabolism/pathology
Funding
  • Swiss National Science Foundation - FNRS
Citation (ISO format)
ROMERO, Yannick et al. Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects. In: PloS one, 2011, vol. 6, n° 10, p. e25241. doi: 10.1371/journal.pone.0025241
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1932-6203
611views
280downloads

Technical informations

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