Professional article
Open access

Towards an in vivo portrait of pancreatic beta cells : the bare essentials

Published inTreatment strategies. Diabetes, vol. 3, p. 43-47
Publication date2011

Many questions about the natural history of both type 1 and type 2 diabetes remain unanswered, mostly because what we have experimentally learned has been derived from in vitro studies, which only partially mimic the complex situation of the living animal/human. Furthermore, the in vivo observations that can now be made in living individuals provide but indirect evaluations of beta cell mass and functions (in humans), or allow for testing only a single time point along the sequence of events that leads to the onset, maintenance and evolution of the diseases (in animal models). As a consequence, we lack a solid scientific basis to develop targeted therapies, and to monitor their actual effects, specifically in the human clinic. In view of the explosive diabetic epidemic, a method that could non invasively and repeatedly evaluate both beta cell mass and function, the two parameters whose alterations are key to most forms of diabetes, is now most needed.

  • Beta cell
  • Pancreatic islets
  • Imaging
  • MRI
  • PET
  • Bioluminescence
Citation (ISO format)
VINET, Laurent et al. Towards an in vivo portrait of pancreatic beta cells : the bare essentials. In: Treatment strategies. Diabetes, 2011, vol. 3, p. 43–47.
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Article (Published version)
  • PID : unige:23579
ISSN of the journal2046-5793

Technical informations

Creation10/25/2012 8:10:00 AM
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