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Towards an in vivo portrait of pancreatic beta cells : the bare essentials

Nabuurs, Christine
Immonen, Rikka
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Published in Treatment strategies. Diabetes. 2011, vol. 3, p. 43-47
Abstract Many questions about the natural history of both type 1 and type 2 diabetes remain unanswered, mostly because what we have experimentally learned has been derived from in vitro studies, which only partially mimic the complex situation of the living animal/human. Furthermore, the in vivo observations that can now be made in living individuals provide but indirect evaluations of beta cell mass and functions (in humans), or allow for testing only a single time point along the sequence of events that leads to the onset, maintenance and evolution of the diseases (in animal models). As a consequence, we lack a solid scientific basis to develop targeted therapies, and to monitor their actual effects, specifically in the human clinic. In view of the explosive diabetic epidemic, a method that could non invasively and repeatedly evaluate both beta cell mass and function, the two parameters whose alterations are key to most forms of diabetes, is now most needed.
Keywords Beta cellPancreatic isletsImagingMRIPETBioluminescence
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Research group Couplage cellulaire et connexines (136)
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VINET, Laurent et al. Towards an in vivo portrait of pancreatic beta cells : the bare essentials. In: Treatment strategies. Diabetes, 2011, vol. 3, p. 43-47. https://archive-ouverte.unige.ch/unige:23579

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Deposited on : 2012-10-29

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