Towards an in vivo portrait of pancreatic beta cells : the bare essentials

Article Article professionnel Article Towards an in vivo portrait of pancreatic beta cells : the bare essentials eng 2011 author Vinet Laurent 698286 author Lamprianou Smaragda 689484 author Goulley Joan 744345 author Nabuurs Christine author Immonen Rikka author Babic Andréj 742457 author Sahoo Dhananjaya 746784 author Lange Norbert 135650 author Montet Xavier author Meda Paolo 26346 43-47 2046-5793 Many questions about the natural history of both type 1 and type 2 diabetes remain unanswered, mostly because what we have experimentally learned has been derived from in vitro studies, which only partially mimic the complex situation of the living animal/human. Furthermore, the in vivo observations that can now be made in living individuals provide but indirect evaluations of beta cell mass and functions (in humans), or allow for testing only a single time point along the sequence of events that leads to the onset, maintenance and evolution of the diseases (in animal models). As a consequence, we lack a solid scientific basis to develop targeted therapies, and to monitor their actual effects, specifically in the human clinic. In view of the explosive diabetic epidemic, a method that could non invasively and repeatedly evaluate both beta cell mass and function, the two parameters whose alterations are key to most forms of diabetes, is now most needed. Beta cell Pancreatic islets Imaging MRI PET Bioluminescence Dewey 612 Dewey 615 31 Section des sciences pharmaceutiques 17 134 Département de physiologie cellulaire et métabolisme 21C false 107 Couplage cellulaire et connexines 136 Treatment strategies. Diabetes 3 ae8949c5-52e7-4c11-bf41-36235f2c3b98 Article (Published version) Public Laurentrev.pdf 1999919 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Towards an in vivo portrait of pancreatic beta cells : the bare essentials	Treatment strategies. Diabetes			2011	716	236

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Sahoo, Dhananjaya