A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

Favreau, Philippe; Benoit, Evelyne; Hocking, Henry G; Carlier, Ludovic; D' hoedt, Dieter; Leipold, Enrico; Markgraf, René; Schlumberger, Sébastien; Córdova, Marco A; Gaertner, Hubert François; Paolini-Bertrand, Marianne; Hartley, Oliver; Tytgat, Jan; Heinemann, Stefan H; Bertrand, Daniel; Boelens, Rolf; Stocklin, Reto; Molgó, Jordi

doi:10.1111/j.1476-5381.2012.01837.x

Scientific article

English

A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

ContributorsFavreau, Philippe; Benoit, Evelyne; Hocking, Henry G; Carlier, Ludovic; D' hoedt, Dieter; Leipold, Enrico; Markgraf, René; Schlumberger, Sébastien; Córdova, Marco A; Gaertner, Hubert François; Paolini-Bertrand, Marianne; Hartley, Oliver

; Tytgat, Jan; Heinemann, Stefan H; Bertrand, Daniel; Boelens, Rolf; Stocklin, Reto; Molgó, Jordi

Published inBritish journal of pharmacology, vol. 166, no. 5, p. 1654-1668

Publication date2012

Abstract

The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations and molecular targets to assess its potential as a myorelaxant.

Affiliation entities

Research groups

Protein and peptide engineering for medicine (835)

Citation (ISO format)

FAVREAU, Philippe et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. In: British journal of pharmacology, 2012, vol. 166, n° 5, p. 1654–1668. doi: 10.1111/j.1476-5381.2012.01837.x

Article (Published version)

Identifiers

PID : unige:23511
DOI : 10.1111/j.1476-5381.2012.01837.x
PMID : 22229737

Journal ISSN0007-1188

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A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

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