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Title

A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors
Authors
Favreau, Philippe
Benoit, Evelyne
Hocking, Henry G
Carlier, Ludovic
D' hoedt, Dieter
Leipold, Enrico
Markgraf, René
Schlumberger, Sébastien
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Published in British Journal of Pharmacology. 2012, vol. 166, no. 5, p. 1654-68
Abstract The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations and molecular targets to assess its potential as a myorelaxant.
Identifiers
PMID: 22229737
Full text
Article (Published version) (1.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research group HIV (835)
Citation
(ISO format) 		FAVREAU, Philippe et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. In: British Journal of Pharmacology, 2012, vol. 166, n° 5, p. 1654-68. https://archive-ouverte.unige.ch/unige:23511

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Deposited on : 2012-10-19

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