A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

Favreau, Philippe; Benoit, Evelyne; Hocking, Henry G; Carlier, Ludovic; D' hoedt, Dieter; Leipold, Enrico; Markgraf, René; Schlumberger, Sébastien; Córdova, Marco A; Gaertner, Hubert François; Paolini-Bertrand, Marianne; Hartley, Oliver; Tytgat, Jan; Heinemann, Stefan H; Bertrand, Daniel; Boelens, Rolf; Stocklin, Reto; Molgó, Jordi

doi:10.1111/j.1476-5381.2012.01837.x

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Title		A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors
Authors		Favreau, Philippe Benoit, Evelyne Hocking, Henry G Carlier, Ludovic D' hoedt, Dieter Leipold, Enrico Markgraf, René Schlumberger, Sébastien Córdova, Marco A Gaertner, Hubert François Paolini-Bertrand, Marianne Hartley, Oliver Tytgat, Jan Heinemann, Stefan H Bertrand, Daniel Boelens, Rolf Stocklin, Reto Molgó, Jordi show all authors [1 - 18]
Published in		British Journal of Pharmacology. 2012, vol. 166, no. 5, p. 1654-68
Abstract		The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations and molecular targets to assess its potential as a myorelaxant.
Identifiers		DOI: 10.1111/j.1476-5381.2012.01837.x PMID: 22229737
Full text		Article (Published version) (1.6 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research group		HIV (835)
Citation (ISO format)		FAVREAU, Philippe et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. In: British Journal of Pharmacology, 2012, vol. 166, n° 5, p. 1654-68. doi: 10.1111/j.1476-5381.2012.01837.x https://archive-ouverte.unige.ch/unige:23511