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A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

Publié dansBritish journal of pharmacology, vol. 166, no. 5, p. 1654-1668
Date de publication2012
Résumé

The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations and molecular targets to assess its potential as a myorelaxant.

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Citation (format ISO)
FAVREAU, Philippe et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. In: British journal of pharmacology, 2012, vol. 166, n° 5, p. 1654–1668. doi: 10.1111/j.1476-5381.2012.01837.x
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ISSN du journal0007-1188
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Informations techniques

Création10/10/2012 16:07:00
Première validation10/10/2012 16:07:00
Heure de mise à jour14/03/2023 17:43:23
Changement de statut14/03/2023 17:43:23
Dernière indexation16/01/2024 00:24:54
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