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New Insights in Pharmaceutical Analysis

Contributors

Guillarme, Davy; Schappler, Julie; Boccard, Julien; Veuthey, Jean-Luc; Rudaz, Serge

Published in

Chimia, vol. 66, no. 5, p. 330-334

Publication date

2012

Abstract

The research unit of pharmaceutical analytical chemistry (PAC) has been active in the field of separation sciences for many years. Liquid chromatography (LC) and its latest improvements such as ultra-high performance chromatography (UHPLC) and supercritical fluid chromatography (SFC) are deeply and thoroughly studied, from a fundamental viewpoint to its various application capabilities. Electro-driven separations such as capillary electrophoresis (CE) are also a major field of interest, especially for macromolecules, and low cost. All these techniques are investigated with various detection modes including mass spectrometry (MS) for various applications where high sensitivity and selectivity is needed. Extracting the relevant information from the overwhelming amount of data generated by modern analytical platforms has become an important issue for knowledge discovery in various research fields. The appropriate treatment of such data is therefore of crucial importance to provide valuable information. Numerous works in our research group have demonstrated the usefulness of statistical and mathematical methodologies to improve quality of the results. Therefore, well-established chemometric approaches (e.g. design of experiments, multivariate data analysis, etc.) are implemented to optimize the analytical process from method development to data analysis.

Keywords

  • Capillary electrophoresis
  • Chemometrics
  • Fast analysis
  • Liquid chromatography
  • Mass spectrometry
  • Metabolism
  • Metabolomics
  • Toxicological analysis

UNIGE affiliation entities

Citation (ISO format)

GUILLARME, Davy et al. New Insights in Pharmaceutical Analysis. In: Chimia, 2012, vol. 66, n° 5, p. 330–334. doi: 10.2533/chimia.2012.330

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Article (Published version)

Identifiers

Journal ISSN

0009-4293
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427downloads

Technical informations

Creation

09/10/2012 15:04:00

First validation

09/10/2012 15:04:00

Update

14/03/2023 17:42:32

Status update

14/03/2023 17:42:32

Last indexation

18/03/2025 09:21:04
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