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Administration transdermique non-invasive par iontophorèse de protéines: démonstration de la faisabilité et de la compréhension du mécanisme d'électrotransport

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Defense Thèse de doctorat : Univ. Genève, 2011 - Sc. 4362 - 2011/10/18
Abstract Recent advances in biotechnology have led to a rapid expansion in the use of protein based therapeutics. Translation of pharmacological activity in vitro to a clinically effective therapeutic requires a suitable drug delivery system. Iontophoresis is a non invasive technique and offers a promising alternative. Chapter 1 presents a novel method of visualizing transdermal protein distribution after iontophoresis. Chapter 2, 3 and 4 (RNAse-A, RNAse-T1 and hbFGF respectively) discusses the possibility of delivering medium size proteins into and across the skin. Chapter 5, 6 and 7 (Lysozyme, IFN-β-1b and IGF-1) describes the factors which can limit the transdermal delivery of proteins. Chapter 8 talks about the computational methods to calculate various three-dimensional molecular properties of proteins which were then correlated with electrotransport data. Chapter 9 of this thesis is focused on briefly reviewing different stratum corneum ablation techniques, which can be used to further improve iontophoretic delivery.
Keywords ProteinIontophoresisTransdermalFormulationDelivery
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URN: urn:nbn:ch:unige-229120
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DUBEY, Sachin Kumar. Administration transdermique non-invasive par iontophorèse de protéines: démonstration de la faisabilité et de la compréhension du mécanisme d'électrotransport. Université de Genève. Thèse, 2011. https://archive-ouverte.unige.ch/unige:22912

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Deposited on : 2012-09-17

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