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Doctoral thesis
OA Policy
English

Administration transdermique non-invasive par iontophorèse de protéines: démonstration de la faisabilité et de la compréhension du mécanisme d'électrotransport

Contributors

Dubey, Sachin Kumar

Directors

Scapozza, Leonardo; Kalia, Yogeshvar

Defense date

2011-10-18

Abstract

Recent advances in biotechnology have led to a rapid expansion in the use of protein based therapeutics. Translation of pharmacological activity in vitro to a clinically effective therapeutic requires a suitable drug delivery system. Iontophoresis is a non invasive technique and offers a promising alternative. Chapter 1 presents a novel method of visualizing transdermal protein distribution after iontophoresis. Chapter 2, 3 and 4 (RNAse-A, RNAse-T1 and hbFGF respectively) discusses the possibility of delivering medium size proteins into and across the skin. Chapter 5, 6 and 7 (Lysozyme, IFN-β-1b and IGF-1) describes the factors which can limit the transdermal delivery of proteins. Chapter 8 talks about the computational methods to calculate various three-dimensional molecular properties of proteins which were then correlated with electrotransport data. Chapter 9 of this thesis is focused on briefly reviewing different stratum corneum ablation techniques, which can be used to further improve iontophoretic delivery.

Keywords

  • Protein
  • Iontophoresis
  • Transdermal
  • Formulation
  • Delivery

UNIGE affiliation entities

Citation (ISO format)

DUBEY, Sachin Kumar. Administration transdermique non-invasive par iontophorèse de protéines: démonstration de la faisabilité et de la compréhension du mécanisme d’électrotransport. Doctoral Thesis, 2011. doi: 10.13097/archive-ouverte/unige:22912

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Thesis

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Technical informations

Creation

13/09/2012 11:20:00

First validation

13/09/2012 11:20:00

Update

14/03/2023 17:40:51

Status update

14/03/2023 17:40:51

Last indexation

13/05/2025 16:05:25
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