At Colquijirca, central Peru, a predominantly dacitic Miocene diatreme-dome complex of 12.4 to 12.7 Ma (40Ar/39Ar biotite ages), is spatially related to two distinct mineralization types. Disseminated Au–(Ag) associated with advanced argillic alteration and local vuggy silica typical of high- sulfidation epithermal ores are hosted exclusively within the volcanic center at Marcapunta. A second economically more important mineralization type is characterized as "Cordilleran base metal lode and replacement deposits." These ores are hosted in Mesozoic and Cenozoic carbonate rocks surrounding the diatreme-dome complex and are zoned outward from pyrite–enargite–quartz–alunite to pyrite–chalcopyrite–dickite–kaolinite to pyrite–sphalerite–galena–kaolinite–siderite. Alunite samples related to the Au–(Ag) epithermal ores have been dated by the 40Ar/39Ar method at 11.3–11.6 Ma and those from the Cordilleran base metal ores in the northern part of the district (Smelter and Colquijirca) at 10.6–10.8 Ma. The significant time gap (~0.5 My) between the ages of the two mineralization types in the Colquijirca district indicates they were formed by different hydrothermal events within the same magmatic cycle. The estimated time interval between the younger mineralization event (base metal mineralization) at ~10.6 Ma and the ages of ~12.5 Ma obtained on biotites from unmineralized dacitic domes flanking the vicinity of the diatreme vent, suggest a minimum duration of the magmatic–hydrothermal cycle of around 2 Ma. This study on the Colquijirca district offers for the first time precise absolute ages indicating that the Cordilleran base metal lode and replacement deposits were formed by a late hydrothermal event in an intrusive-related district, in this case post Au–(Ag) high-sulfidation epithermal mineralization.