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Scientific article
Meta-analysis
Open access
English

Mitochondrial calcium handling during ischemia-induced cell death in neurons

Published inBiochimie, vol. 93, no. 12, p. 2060-2067
Publication date2011
Abstract

Mitochondria sense and shape cytosolic Ca(2+) signals by taking up and subsequently releasing Ca(2+) ions during physiological and pathological Ca(2+) elevations. Sustained elevations in the mitochondrial matrix Ca(2+) concentration are increasingly recognized as a defining feature of the intracellular cascade of lethal events that occur in neurons during cerebral ischemia. Here, we review the recently identified transport proteins that mediate the fluxes of Ca(2+) across mitochondria and discuss the implication of the permeability transition pore in decoding the abnormally sustained mitochondrial Ca(2+) elevations that occur during cerebral ischemia.

Keywords
  • Animals
  • Brain Ischemia/metabolism/pathology/physiopathology
  • Calcium/metabolism
  • Calcium-Binding Proteins
  • Cell Death
  • Cell Hypoxia
  • Humans
  • Mitochondria/metabolism
  • Mitochondrial Membrane Transport Proteins/metabolism
  • Neurons/metabolism/pathology
Citation (ISO format)
GOURIOU, Yves et al. Mitochondrial calcium handling during ischemia-induced cell death in neurons. In: Biochimie, 2011, vol. 93, n° 12, p. 2060–2067. doi: 10.1016/j.biochi.2011.08.001
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Article (Published version)
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ISSN of the journal0300-9084
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Technical informations

Creation06/04/2012 8:16:00 PM
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