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Title

Stromal issues in cervical cancer: a review of the role and function of basement membrane, stroma, immune response and angiogenesis in cervical cancer development
Authors
Sahebali, Shaira
Van den Eynden, Gert
Murta, Eddie F
Michelin, Marcia A
Cusumano, Pino
Petignat, Patrick
Bogers, Johannes J
Published in European Journal of Cancer Prevention. 2010, vol. 19, no. 3, p. 204-15
Abstract The carcinogenesis of cervical carcinoma implies an intricate interplay of neoplastic, human papillomavirus infected epithelial cells and stromal tissue, in which different factors have distinct but interacting influence. Persistent infection with an oncogenic human papillomavirus type may lead to epithelial dysplasia with progressive severity. To access the adjacent stromal tissue, tumour cells have to breach the basement membrane. The stroma partly controls tumour growth, invasion and angiogenesis. Last but not least there is considerable influence of the immune response. In this review we describe the importance of various stromal factors in carcinogenesis of cervical cancer.
Keywords Basement Membrane/physiology — Female — Humans — Matrix Metalloproteinases/physiology — Neovascularization, Pathologic/etiology — Stromal Cells/physiology — Uterine Cervical Neoplasms/blood supply/etiology/immunology/pathology
Identifiers
PMID: 20101182
Full text
Article (Published version) (401 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group Groupe Petignat Patrick (933)
Citation
(ISO format) 		SAHEBALI, Shaira et al. Stromal issues in cervical cancer: a review of the role and function of basement membrane, stroma, immune response and angiogenesis in cervical cancer development. In: European Journal of Cancer Prevention, 2010, vol. 19, n° 3, p. 204-15. doi: 10.1097/CEJ.0b013e32833720de https://archive-ouverte.unige.ch/unige:21452

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Deposited on : 2012-05-25

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