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Title

Role of decidua in trophoblastic invasion
Authors
Cohen, Marie-Benoîte
Wuillemin-Rambosson, Christine Gabrielle
Irion, Olivier
Bischof, Paul
Published in Neuroendocrinology Letters. 2010, vol. 31, no. 2, p. 193-7
Abstract Proliferation, migration and invasion of trophoblastic cells into the maternal endometrium are essential steps in human embryo implantation and placentation. Trophoblast invasion is normally limited in time, only during first and early second trimester of pregnancy, and in space, limited to the endometrium and the proximal third of myometrium. This process requires among other factors: the metalloproteinases (MMP) 2 and 9. Shallow trophoblast invasion is associated with pathologies including preeclampsia and fetal growth restriction whereas unlimited invasion is associated with hydatidiform moles and choriocarcinomas.
Keywords Cell Proliferation — Cells, Cultured — Coculture Techniques — Decidua/cytology — Embryo Implantation/physiology — Female — Humans — Matrix Metalloproteinase 2/secretion — Matrix Metalloproteinase 9/secretion — Placenta/cytology — Pregnancy — Trophoblasts/cytology
Identifiers
PMID: 20424580
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Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups Groupe Irion Olivier/Boulvain Michel (gynécologie et obstétrique) (272)
Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
Citation
(ISO format) 		COHEN, Marie-Benoîte et al. Role of decidua in trophoblastic invasion. In: Neuroendocrinology Letters, 2010, vol. 31, n° 2, p. 193-7. https://archive-ouverte.unige.ch/unige:21428

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Deposited on : 2012-05-25

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