en
Scientific article
English

Role of decidua in trophoblastic invasion

Published inNeuro-endocrinology letters, vol. 31, no. 2, p. 193-197
Publication date2010
Abstract

Proliferation, migration and invasion of trophoblastic cells into the maternal endometrium are essential steps in human embryo implantation and placentation. Trophoblast invasion is normally limited in time, only during first and early second trimester of pregnancy, and in space, limited to the endometrium and the proximal third of myometrium. This process requires among other factors: the metalloproteinases (MMP) 2 and 9. Shallow trophoblast invasion is associated with pathologies including preeclampsia and fetal growth restriction whereas unlimited invasion is associated with hydatidiform moles and choriocarcinomas.

Keywords
  • Cell Proliferation
  • Cells, Cultured
  • Coculture Techniques
  • Decidua/cytology
  • Embryo Implantation/physiology
  • Female
  • Humans
  • Matrix Metalloproteinase 2/secretion
  • Matrix Metalloproteinase 9/secretion
  • Placenta/cytology
  • Pregnancy
  • Trophoblasts/cytology
Citation (ISO format)
COHEN, Marie-Benoîte et al. Role of decidua in trophoblastic invasion. In: Neuro-endocrinology letters, 2010, vol. 31, n° 2, p. 193–197.
Identifiers
ISSN of the journal0172-780X
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