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Role of decidua in trophoblastic invasion

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Published in Neuroendocrinology Letters. 2010, vol. 31, no. 2, p. 193-7
Abstract Proliferation, migration and invasion of trophoblastic cells into the maternal endometrium are essential steps in human embryo implantation and placentation. Trophoblast invasion is normally limited in time, only during first and early second trimester of pregnancy, and in space, limited to the endometrium and the proximal third of myometrium. This process requires among other factors: the metalloproteinases (MMP) 2 and 9. Shallow trophoblast invasion is associated with pathologies including preeclampsia and fetal growth restriction whereas unlimited invasion is associated with hydatidiform moles and choriocarcinomas.
Keywords Cell ProliferationCells, CulturedCoculture TechniquesDecidua/cytologyEmbryo Implantation/physiologyFemaleHumansMatrix Metalloproteinase 2/secretionMatrix Metalloproteinase 9/secretionPlacenta/cytologyPregnancyTrophoblasts/cytology
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PMID: 20424580
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Research groups Groupe Irion Olivier/Boulvain Michel (gynécologie et obstétrique) (272)
Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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COHEN, Marie-Benoîte et al. Role of decidua in trophoblastic invasion. In: Neuroendocrinology Letters, 2010, vol. 31, n° 2, p. 193-7. https://archive-ouverte.unige.ch/unige:21428

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Deposited on : 2012-05-25

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