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Role of decidua in trophoblastic invasion

Published in Neuro-endocrinology letters. 2010, vol. 31, no. 2, p. 193-7
Abstract Proliferation, migration and invasion of trophoblastic cells into the maternal endometrium are essential steps in human embryo implantation and placentation. Trophoblast invasion is normally limited in time, only during first and early second trimester of pregnancy, and in space, limited to the endometrium and the proximal third of myometrium. This process requires among other factors: the metalloproteinases (MMP) 2 and 9. Shallow trophoblast invasion is associated with pathologies including preeclampsia and fetal growth restriction whereas unlimited invasion is associated with hydatidiform moles and choriocarcinomas.
Keywords Cell ProliferationCells, CulturedCoculture TechniquesDecidua/cytologyEmbryo Implantation/physiologyFemaleHumansMatrix Metalloproteinase 2/secretionMatrix Metalloproteinase 9/secretionPlacenta/cytologyPregnancyTrophoblasts/cytology
PMID: 20424580
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Research groups Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
Martinez De Tejada Begona (272)
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COHEN, Marie-Benoîte et al. Role of decidua in trophoblastic invasion. In: Neuro-endocrinology letters, 2010, vol. 31, n° 2, p. 193-7. https://archive-ouverte.unige.ch/unige:21428

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Deposited on : 2012-05-25

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