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Calcium uptake mechanisms of mitochondria
|Published in||Biochimica et Biophysica Acta. 2010, vol. 1797, no. 6-7, p. 907-912|
|Abstract||The ability of mitochondria to capture Ca2+ ions has important functional implications for cells, because mitochondria shape cellular Ca2+ signals by acting as a Ca2+ buffer and respond to Ca2+ elevations either by increasing the cell energy supply or by triggering the cell death program of apoptosis. A mitochondrial Ca2+ channel known as the uniporter drives the rapid and massive entry of Ca2+ ions into mitochondria. The uniporter operates at high, micromolar cytosolic Ca2+ concentrations that are only reached transiently in cells, near Ca2+ release channels. Mitochondria can also take up Ca2+ at low, nanomolar concentrations, but this high affinity mode of Ca2+ uptake is not well characterized. Recently, leucine-zipper-EF hand-containing transmembrane region (Letm1) was proposed to be an electrogenic 1:1 mitochondrial Ca2+/H+ antiporter that drives the uptake of Ca2+ into mitochondria at nanomolar cytosolic Ca2+ concentrations. In this article, we will review the properties of the Ca2+ import systems of mitochondria and discuss how Ca2+ uptake via an electrogenic 1:1 Ca2+/H+ antiport challenges our current thinking of the mitochondrial Ca2+ uptake mechanism.|
|Keywords||Animals — Antiporters/metabolism — Calcium/*metabolism — Calcium Channels/metabolism — Calcium Signaling — Calcium-Binding Proteins/metabolism — Cation Transport Proteins/metabolism — Humans — Ion Transport — Membrane Proteins/metabolism — Mitochondria/*metabolism — Models, Biological|
|Research group||Signaux intracellulaires (210)|
|SANTO-DOMINGO, Jaime, DEMAUREX, Nicolas. Calcium uptake mechanisms of mitochondria. In: Biochimica et Biophysica Acta, 2010, vol. 1797, n° 6-7, p. 907-912. https://archive-ouverte.unige.ch/unige:21286|