en
Scientific article
Review
English

Calcium uptake mechanisms of mitochondria

Published inBiochimica et biophysica acta, vol. 1797, no. 6-7, p. 907-912
Publication date2010
Abstract

The ability of mitochondria to capture Ca2+ ions has important functional implications for cells, because mitochondria shape cellular Ca2+ signals by acting as a Ca2+ buffer and respond to Ca2+ elevations either by increasing the cell energy supply or by triggering the cell death program of apoptosis. A mitochondrial Ca2+ channel known as the uniporter drives the rapid and massive entry of Ca2+ ions into mitochondria. The uniporter operates at high, micromolar cytosolic Ca2+ concentrations that are only reached transiently in cells, near Ca2+ release channels. Mitochondria can also take up Ca2+ at low, nanomolar concentrations, but this high affinity mode of Ca2+ uptake is not well characterized. Recently, leucine-zipper-EF hand-containing transmembrane region (Letm1) was proposed to be an electrogenic 1:1 mitochondrial Ca2+/H+ antiporter that drives the uptake of Ca2+ into mitochondria at nanomolar cytosolic Ca2+ concentrations. In this article, we will review the properties of the Ca2+ import systems of mitochondria and discuss how Ca2+ uptake via an electrogenic 1:1 Ca2+/H+ antiport challenges our current thinking of the mitochondrial Ca2+ uptake mechanism.

Keywords
  • Animals
  • Antiporters/metabolism
  • Calcium/*metabolism
  • Calcium Channels/metabolism
  • Calcium Signaling
  • Calcium-Binding Proteins/metabolism
  • Cation Transport Proteins/metabolism
  • Humans
  • Ion Transport
  • Membrane Proteins/metabolism
  • Mitochondria/*metabolism
  • Models, Biological
Citation (ISO format)
SANTO-DOMINGO, Jaime, DEMAUREX, Nicolas. Calcium uptake mechanisms of mitochondria. In: Biochimica et biophysica acta, 2010, vol. 1797, n° 6-7, p. 907–912. doi: 10.1016/j.bbabio.2010.01.005
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0006-3002
421views
0downloads

Technical informations

Creation05/23/2012 8:57:08 AM
First validation05/23/2012 8:57:08 AM
Update time03/14/2023 5:35:39 PM
Status update03/14/2023 5:35:39 PM
Last indexation02/12/2024 8:19:09 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack