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Scientific article
English

"Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance

Published inJournal of virology, vol. 84, no. 11, p. 5842-5845
Publication date2010
Abstract

Resistance of human immunodeficiency virus type 1 (HIV-1) to small-molecule CCR5 inhibitors is well demonstrated, but resistance to macromolecular CCR5 inhibitors (e.g., PSC-RANTES) that act by both CCR5 internalization and receptor blockade had not been reported until recently (3). The report of a single simian-human immunodeficiency virus SHIV(SF162-p3) variant with one V3 and one gp41 sequence change in gp160 that conferred both altered replicative fitness and resistance to PSC-RANTES was therefore surprising. We introduced the same two mutations into both the parental HIV-1(SF162) and the macaque-adapted SHIV(SF162-p3) and found minor differences in entry fitness but no changes in sensitivity to inhibition by either PSC-RANTES or the small-molecule allosteric inhibitor TAK-779. We attribute the earlier finding to confounding fitness effects with inhibitor sensitivity.

Keywords
  • Animals
  • Anti-HIV Agents/pharmacology
  • Chemokine CCL5/*pharmacology
  • Drug Resistance/*genetics
  • HIV-1/*genetics/pathogenicity
  • Humans
  • Macaca
  • *Mutation
  • Receptors, CCR5/antagonists & inhibitors
  • Receptors, Virus/antagonists & inhibitors
  • Simian immunodeficiency virus/*genetics/pathogenicity
  • Virus Replication/drug effects
Research group
Citation (ISO format)
NEDELLEC, Rebecca et al. ‘Resistance’ to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance. In: Journal of virology, 2010, vol. 84, n° 11, p. 5842–5845. doi: 10.1128/JVI.01907-09
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ISSN of the journal0022-538X
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