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Title

"Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance

Authors
Nedellec, Rebecca
Coetzer, Mia
Lederman, Michael M.
Mosier, Donald E.
Published in Journal of Virology. 2010, vol. 84, no. 11, p. 5842-5845
Abstract Resistance of human immunodeficiency virus type 1 (HIV-1) to small-molecule CCR5 inhibitors is well demonstrated, but resistance to macromolecular CCR5 inhibitors (e.g., PSC-RANTES) that act by both CCR5 internalization and receptor blockade had not been reported until recently (3). The report of a single simian-human immunodeficiency virus SHIV(SF162-p3) variant with one V3 and one gp41 sequence change in gp160 that conferred both altered replicative fitness and resistance to PSC-RANTES was therefore surprising. We introduced the same two mutations into both the parental HIV-1(SF162) and the macaque-adapted SHIV(SF162-p3) and found minor differences in entry fitness but no changes in sensitivity to inhibition by either PSC-RANTES or the small-molecule allosteric inhibitor TAK-779. We attribute the earlier finding to confounding fitness effects with inhibitor sensitivity.
Keywords AnimalsAnti-HIV Agents/pharmacologyChemokine CCL5/*pharmacologyDrug Resistance/*geneticsHIV-1/*genetics/pathogenicityHumansMacaca*MutationReceptors, CCR5/antagonists & inhibitorsReceptors, Virus/antagonists & inhibitorsSimian immunodeficiency virus/*genetics/pathogenicityVirus Replication/drug effects
Identifiers
PMID: 20335248
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Research group HIV (835)
Citation
(ISO format)
NEDELLEC, Rebecca et al. "Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance. In: Journal of Virology, 2010, vol. 84, n° 11, p. 5842-5845. https://archive-ouverte.unige.ch/unige:21173

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Deposited on : 2012-05-23

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