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Scientific article
Open access
English

Early disturbances of gamma band dynamics in mild cognitive impairment

Published inJournal of neural transmission, vol. 117, no. 4, p. 489-498
Collection
  • Open Access - Licence nationale Springer
Publication date2010
Abstract

Recent studies have indicated that gamma band oscillations participate in the temporal binding needed for the synchronization of cortical networks involved in short-term memory and attentional processes. To date, no study has explored the temporal dynamics of gamma band in the early stages of dementia. At baseline, gamma band analysis was performed in 29 cases with mild cognitive impairment (MCI) during the n-back task. Based on phase diagrams, multiple linear regression models were built to explore the relationship between the cognitive status and gamma oscillation changes over time. Individual measures of phase diagram complexity were made using fractal dimension values. After 1 year, all cases were assessed neuropsychologically using the same battery. A total of 16 MCI patients showed progressive cognitive decline (PMCI) and 13 remained stable (SMCI). When adjusted for gamma values at lag -2, and -3 ms, PMCI cases displayed significantly lower average changes in gamma values than SMCI cases both in detection and 2-back tasks. Gamma fractal dimension of PMCI cases displayed significantly higher gamma fractal dimension values compared to SMCI cases. This variable explained 11.8% of the cognitive variability in this series. Our data indicate that the progression of cognitive decline in MCI is associated with early deficits in temporal binding that occur during the activation of selective attention processes.

Keywords
  • Aged
  • Aged, 80 and over
  • Brain/*physiopathology
  • Cognition Disorders/*physiopathology
  • Disease Progression
  • Electroencephalography
  • Evoked Potentials
  • Female
  • Follow-Up Studies
  • Fractals
  • Humans
  • Linear Models
  • Male
  • Neuropsychological Tests
  • Periodicity
  • Reaction Time
  • Signal Processing, Computer-Assisted
  • Time Factors
Citation (ISO format)
MISSONNIER, Pascal et al. Early disturbances of gamma band dynamics in mild cognitive impairment. In: Journal of neural transmission, 2010, vol. 117, n° 4, p. 489–498. doi: 10.1007/s00702-010-0384-9
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Article (Published version)
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Identifiers
ISSN of the journal0300-9564
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227downloads

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