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Spatio-temporal dynamics of olfactory processing in the human brain: an event-related source imaging study

Hummel, T.
Published in Neuroscience. 2010, vol. 167, no. 3, p. 700-708
Abstract Although brain structures involved in central nervous olfactory processing in humans have been well identified with functional neuroimaging, little is known about the temporal sequence of their activation. We recorded olfactory event-related potentials (ERP) to H(2)S stimuli presented to the left and right nostril in 12 healthy subjects. Topographic and source analysis identified four distinct processing steps between 200 and 1000 ms. Activation started ipsilateral to the stimulated nostril in the mesial and lateral temporal cortex (amygdala, parahippocampal gyrus, superior temporal gyrus, insula). Subsequently, the corresponding structures on the contralateral side became involved, followed by frontal structures at the end of the activation period. Thus, based on EEG-related data, current results suggest that olfactory information in humans is processed first ipsilaterally to the stimulated nostril and then activates the major relays in olfactory information processing in both hemispheres. Most importantly, the currently described techniques allow the investigation of the spatial processing of olfactory information at a high temporal resolution.
Keywords AdultAmygdala/anatomy & histology/physiologyBrain/*anatomy & histology/*physiologyBrain MappingCerebral Cortex/anatomy & histology/physiologyElectroencephalographyEvoked Potentials/*physiologyFemaleFunctional Laterality/physiologyHumansMaleMiddle AgedOdorsOlfactory Pathways/*anatomy & histology/*physiologyParahippocampal Gyrus/anatomy & histology/physiologyReaction Time/physiologySignal Processing, Computer-AssistedSmell/*physiologyTime FactorsYoung Adult
PMID: 20153813
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Research group Organisation et plasticité des réseaux neuronaux cérébraux (148)
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LASCANO, Agustina Maria et al. Spatio-temporal dynamics of olfactory processing in the human brain: an event-related source imaging study. In: Neuroscience, 2010, vol. 167, n° 3, p. 700-708. doi: 10.1016/j.neuroscience.2010.02.013 https://archive-ouverte.unige.ch/unige:21073

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Deposited on : 2012-05-23

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