UNIGE document Scientific Article
previous document  unige:21069  next document
add to browser collection
Title

Oxidized ATP inhibits T-cell-mediated autoimmunity

Authors
Lang, Philipp A.
Funkner, Pauline
Shaabani, Namir
Meryk, Andreas
Krings, Caroline
Barthuber, Carmen
Recher, Mike
show hidden authors show all authors [1 - 12]
Published in European Journal of Immunology. 2010, vol. 40, no. 9, p. 2401-2408
Abstract T cells directed against self antigens play an important role in several autoimmune diseases. The available immunosuppressive compounds used to treat autoimmune diseases are limited, and often they have side effects that limit their application. T cells express ATP receptors, which could be new target molecules to treat autoimmune disease. Here we analyzed the effect of oxidized ATP (oxATP), an inhibitor of the ATP receptor P2rx7, in different murine models of T-cell-mediated autoimmune diseases. Treatment with oxATP inhibited proliferation and effector function of T cells. In the systems we used, oxATP did not obviously interfere with the innate immune response, but strongly reduced antigen-specific T-cell responses. This treatment ameliorated T-cell-mediated autoimmune type I diabetes and autoimmune encephalitis in mice. In conclusion, oxATP was found to strongly inhibit activated T cells and could thus be used to target T-cell-mediated autoimmune disease.
Keywords Adenosine Triphosphate/administration & dosage/*analogs & derivativesAnimalsApoptosis/drug effects/immunologyAutoimmunity/drug effectsCD4-Positive T-Lymphocytes/*drug effects/immunology/metabolism/pathologyCD8-Positive T-Lymphocytes/*drug effects/immunology/metabolism/pathologyCell Proliferation/drug effectsCells, CulturedCytotoxicity, Immunologic/drug effectsDiabetes Mellitus, Type 1/drug therapy/immunology/*metabolism/pathologyDisease Models, AnimalEncephalomyelitis, Autoimmune, Experimental/drugTherapy/immunology/pathology/physiopathologyFemaleInterferon-gamma/biosynthesis/geneticsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Purinergic P2/genetics/metabolismReceptors, Purinergic P2X7Spinal Cord/*drug effects/pathology
Identifiers
PMID: 20683833
Full text
Structures
Research group La Sclérose en plaques (908)
Citation
(ISO format)
LANG, Philipp A. et al. Oxidized ATP inhibits T-cell-mediated autoimmunity. In: European Journal of Immunology, 2010, vol. 40, n° 9, p. 2401-2408. https://archive-ouverte.unige.ch/unige:21069

248 hits

0 download

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :