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Scientific article
English

Diffusion-weighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS

Contributors

Kunz, Nicolas; Cudalbu, C.; Mlynarik, V.; Hüppi, Petra Susan; Sizonenko, Stéphane; Gruetter, Rolf

Published in

Magnetic resonance in medicine, vol. 64, no. 4, p. 939-946

Publication date

2010

Abstract

Quantification of short-echo time proton magnetic resonance spectroscopy results in >18 metabolite concentrations (neurochemical profile). Their quantification accuracy depends on the assessment of the contribution of macromolecule (MM) resonances, previously experimentally achieved by exploiting the several fold difference in T(1). To minimize effects of heterogeneities in metabolites T(1), the aim of the study was to assess MM signal contributions by combining inversion recovery (IR) and diffusion-weighted proton spectroscopy at high-magnetic field (14.1 T) and short echo time (= 8 msec) in the rat brain. IR combined with diffusion weighting experiments (with delta/Delta = 1.5/200 msec and b-value = 11.8 msec/mum(2)) showed that the metabolite nulled spectrum (inversion time = 740 msec) was affected by residuals attributed to creatine, inositol, taurine, choline, N-acetylaspartate as well as glutamine and glutamate. While the metabolite residuals were significantly attenuated by 50%, the MM signals were almost not affected (< 8%). The combination of metabolite-nulled IR spectra with diffusion weighting allows a specific characterization of MM resonances with minimal metabolite signal contributions and is expected to lead to a more precise quantification of the neurochemical profile.

Keywords

  • Animals
  • Biopolymers/*analysis
  • Brain/*metabolism
  • Macromolecular Substances/analysis
  • Magnetic Resonance Spectroscopy/*methods
  • Protons
  • Rats
  • Rats, Sprague-Dawley

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

KUNZ, Nicolas et al. Diffusion-weighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS. In: Magnetic resonance in medicine, 2010, vol. 64, n° 4, p. 939–946. doi: 10.1002/mrm.22490

Main files (1)

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Additional URL for this publication

http://onlinelibrary.wiley.com/store/10.1002/mrm.22490/asset/22490_ftp.pdf?v=1&t=h1qgu164&s=6a57d73f16174bdd443c4d04e2e452de44e22484

Journal ISSN

0740-3194
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Technical informations

Creation

23/05/2012 08:49:46

First validation

23/05/2012 08:49:46

Update

14/03/2023 17:33:56

Status update

14/03/2023 17:33:56

Last indexation

29/10/2024 20:03:07
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