

Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931160/pdf/JEM_20092627.pdf
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MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity |
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Authors | ![]() | |
Published in | The Journal of experimental medicine. 2010, vol. 207, no. 9, p. 1891-1905 | |
Abstract | Although plasmacytoid dendritic cells (pDCs) express major histocompatibility complex class II (MHCII) molecules, and can capture, process, and present antigens (Ags), direct demonstrations that they function as professional Ag-presenting cells (APCs) in vivo during ongoing immune responses remain lacking. We demonstrate that mice exhibiting a selective abrogation of MHCII expression by pDCs develop exacerbated experimental autoimmune encephalomyelitis (EAE) as a consequence of enhanced priming of encephalitogenic CD4(+) T cell responses in secondary lymphoid tissues. After EAE induction, pDCs are recruited to lymph nodes and establish MHCII-dependent myelin-Ag-specific contacts with CD4(+) T cells. These interactions promote the selective expansion of myelin-Ag-specific natural regulatory T cells that dampen the autoimmune T cell response. pDCs thus function as APCs during the course of EAE and confer a natural protection against autoimmune disease development that is mediated directly by their ability to present of Ags to CD4(+) T cells in vivo. | |
Keywords | Animals — *Antigen Presentation — *Autoimmunity — B-Lymphocytes/immunology — Cell Differentiation — Cell Proliferation — Cells, Cultured — Dendritic Cells/*immunology — Encephalomyelitis, Autoimmune, Experimental/immunology — Histocompatibility Antigens Class II/*immunology — Mice — Mice, Inbred C57BL — T-Lymphocytes/cytology/*immunology | |
Identifiers | DOI: 10.1084/jem.20092627 PMID: 20696698 | |
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![]() ![]() Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931160/pdf/JEM_20092627.pdf |
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Research groups | Groupe Reith Walter (pathologie et immunologie) (282) Pathologie et immunologie (906) Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843) | |
Citation (ISO format) | IRLA, Magali et al. MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity. In: The Journal of experimental medicine, 2010, vol. 207, n° 9, p. 1891-1905. doi: 10.1084/jem.20092627 https://archive-ouverte.unige.ch/unige:21023 |