MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity

Irla, Magali; Kupfer, Natalia; Suter, Tobias; Lissilaa, Rami; Benkhoucha, Mahdia; Skupsky, Jonathan; Lalive d'Epinay, Patrice; Fontana, Adriano; Reith, Walter; Hugues, Stéphanie

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Title		MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity
Authors		Irla, Magali Kupfer, Natalia Suter, Tobias Lissilaa, Rami Benkhoucha, Mahdia Skupsky, Jonathan Lalive d'Epinay, Patrice Fontana, Adriano Reith, Walter Hugues, Stéphanie show all authors [1 - 10]
Published in		Journal of Experimental Medicine. 2010, vol. 207, no. 9, p. 1891-1905
Abstract		Although plasmacytoid dendritic cells (pDCs) express major histocompatibility complex class II (MHCII) molecules, and can capture, process, and present antigens (Ags), direct demonstrations that they function as professional Ag-presenting cells (APCs) in vivo during ongoing immune responses remain lacking. We demonstrate that mice exhibiting a selective abrogation of MHCII expression by pDCs develop exacerbated experimental autoimmune encephalomyelitis (EAE) as a consequence of enhanced priming of encephalitogenic CD4(+) T cell responses in secondary lymphoid tissues. After EAE induction, pDCs are recruited to lymph nodes and establish MHCII-dependent myelin-Ag-specific contacts with CD4(+) T cells. These interactions promote the selective expansion of myelin-Ag-specific natural regulatory T cells that dampen the autoimmune T cell response. pDCs thus function as APCs during the course of EAE and confer a natural protection against autoimmune disease development that is mediated directly by their ability to present of Ags to CD4(+) T cells in vivo.
Keywords		Animals — Antigen Presentation — Autoimmunity — B-Lymphocytes/immunology — Cell Differentiation — Cell Proliferation — Cells, Cultured — Dendritic Cells/immunology — Encephalomyelitis, Autoimmune, Experimental/immunology — Histocompatibility Antigens Class II/immunology — Mice — Mice, Inbred C57BL — T-Lymphocytes/cytology/*immunology
Identifiers		DOI: 10.1084/jem.20092627 PMID: 20696698
Full text		Article - Limited access to UNIGE Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931160/pdf/JEM_20092627.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research groups		Groupe Reith Walter (pathologie et immunologie) (282) Pathologie et immunologie (906) Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
Citation (ISO format)		IRLA, Magali et al. MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity. In: Journal of Experimental Medicine, 2010, vol. 207, n° 9, p. 1891-1905. https://archive-ouverte.unige.ch/unige:21023