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MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity

Kupfer, Natalia
Suter, Tobias
Lissilaa, Rami
Skupsky, Jonathan
Fontana, Adriano
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Published in The Journal of experimental medicine. 2010, vol. 207, no. 9, p. 1891-1905
Abstract Although plasmacytoid dendritic cells (pDCs) express major histocompatibility complex class II (MHCII) molecules, and can capture, process, and present antigens (Ags), direct demonstrations that they function as professional Ag-presenting cells (APCs) in vivo during ongoing immune responses remain lacking. We demonstrate that mice exhibiting a selective abrogation of MHCII expression by pDCs develop exacerbated experimental autoimmune encephalomyelitis (EAE) as a consequence of enhanced priming of encephalitogenic CD4(+) T cell responses in secondary lymphoid tissues. After EAE induction, pDCs are recruited to lymph nodes and establish MHCII-dependent myelin-Ag-specific contacts with CD4(+) T cells. These interactions promote the selective expansion of myelin-Ag-specific natural regulatory T cells that dampen the autoimmune T cell response. pDCs thus function as APCs during the course of EAE and confer a natural protection against autoimmune disease development that is mediated directly by their ability to present of Ags to CD4(+) T cells in vivo.
Keywords Animals*Antigen Presentation*AutoimmunityB-Lymphocytes/immunologyCell DifferentiationCell ProliferationCells, CulturedDendritic Cells/*immunologyEncephalomyelitis, Autoimmune, Experimental/immunologyHistocompatibility Antigens Class II/*immunologyMiceMice, Inbred C57BLT-Lymphocytes/cytology/*immunology
PMID: 20696698
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Research groups Groupe Reith Walter (pathologie et immunologie) (282)
Pathologie et immunologie (906)
Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
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IRLA, Magali et al. MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity. In: The Journal of experimental medicine, 2010, vol. 207, n° 9, p. 1891-1905. doi: 10.1084/jem.20092627 https://archive-ouverte.unige.ch/unige:21023

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Deposited on : 2012-05-23

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