HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

Rauch, Andri; Nolan, David; Furrer, Hansjakob; McKinnon, Elizabeth; John, Mina; Mallal, Simon; Gaudieri, Silvana; Günthard, Huldrych F.; Schmid, Patrick; Battegay, Manuel; Hirschel, Bernard; Telenti, Amalio; James, Ian

doi:10.1086/588479

Scientific article

English

HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

ContributorsRauch, Andri; Nolan, David; Furrer, Hansjakob; McKinnon, Elizabeth; John, Mina; Mallal, Simon; Gaudieri, Silvana; Günthard, Huldrych F.; Schmid, Patrick; Battegay, Manuel; Hirschel, Bernard; Telenti, Amalio; James, Ian

Published inClinical infectious diseases, vol. 46, no. 12, p. 1921-1925

Publication date2008

Abstract

We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P =.01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.

Keywords

Adult
Aged
Aged, 80 and over
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes/immunology
Female
HIV Infections/drug therapy/genetics/immunology
HLA-B Antigens/genetics
Homozygote
Humans
Male
Middle Aged

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Unité HIV (46)

Citation (ISO format)

RAUCH, Andri et al. HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy. In: Clinical infectious diseases, 2008, vol. 46, n° 12, p. 1921–1925. doi: 10.1086/588479

Article (Accepted version)

Identifiers

PID : unige:2096
DOI : 10.1086/588479
PMID : 18466093

Journal ISSN1058-4838

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HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

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