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Title

HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

Authors
Rauch, Andri
Nolan, David
Furrer, Hansjakob
McKinnon, Elizabeth
John, Mina
Mallal, Simon
Gaudieri, Silvana
Günthard, Huldrych F.
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Published in Clinical Infectious Diseases. 2008, vol. 46, no. 12, p. 1921-5
Abstract We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P =.01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.
Keywords AdultAgedAged, 80 and overAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-Lymphocytes/immunologyFemaleHIV Infections/drug therapy/genetics/immunologyHLA-B Antigens/geneticsHomozygoteHumansMaleMiddle Aged
Identifiers
PMID: 18466093
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Research groups Swiss HIV Cohort Study
Unité HIV (46)
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(ISO format)
RAUCH, Andri et al. HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy. In: Clinical Infectious Diseases, 2008, vol. 46, n° 12, p. 1921-5. https://archive-ouverte.unige.ch/unige:2096

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Deposited on : 2009-06-18

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