en
Scientific article
English

HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

Published inClinical infectious diseases, vol. 46, no. 12, p. 1921-1925
Publication date2008
Abstract

We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P =.01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes/immunology
  • Female
  • HIV Infections/drug therapy/genetics/immunology
  • HLA-B Antigens/genetics
  • Homozygote
  • Humans
  • Male
  • Middle Aged
Research group
Citation (ISO format)
RAUCH, Andri et al. HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy. In: Clinical infectious diseases, 2008, vol. 46, n° 12, p. 1921–1925. doi: 10.1086/588479
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal1058-4838
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