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Scientific article
English

Targeting chemokine receptors in HIV: a status report

Contributors

Kuhmann, Shawn E.; Hartley, Oliver

Published in

Annual review of pharmacology and toxicology, vol. 48, p. 425-461

Publication date

2008

Abstract

Since the identification of CCR5 and CXCR4 as HIV coreceptors a little over a decade ago, there has been hope that coreceptor inhibitors will be able to make an impact on the HIV epidemic, both as novel therapeutic drugs and as agents used in prevention. Significant progress has been made in the understanding of how coreceptor choice might impact HIV pathology and how coreceptor blockade may affect health. In this review, we focus on some of the key issues that are emerging now that CCR5 has been validated as a promising target for HIV prevention strategies and at a time when a CCR5 inhibitor has been approved in the United States as the first in a new class of anti-HIV therapeutic drugs.

Keywords

  • Anti-HIV Agents/pharmacology
  • Drug Delivery Systems
  • Drug Resistance, Viral/physiology
  • HIV Infections/drug therapy/prevention & control
  • HIV-1/drug effects/metabolism
  • Humans
  • Receptors, CCR5/antagonists & inhibitors/metabolism
  • Receptors, CXCR4/antagonists & inhibitors/metabolism

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

KUHMANN, Shawn E., HARTLEY, Oliver. Targeting chemokine receptors in HIV: a status report. In: Annual review of pharmacology and toxicology, 2008, vol. 48, p. 425–461. doi: 10.1146/annurev.pharmtox.48.113006.094847

Main files (1)

Article (Accepted version)

Identifiers

Journal ISSN

0362-1642
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Technical informations

Creation

18/06/2009 12:25:00

First validation

18/06/2009 12:25:00

Update

08/01/2025 10:35:06

Status update

08/01/2025 10:35:06

Last indexation

08/01/2025 10:36:36
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