Scientific article
English

Mitochondrial shape changes: orchestrating cell pathophysiology

Published inEMBO reports, vol. 11, no. 9, p. 678-684
Publication date2010
Abstract

Mitochondria are highly dynamic organelles, the location, size and distribution of which are controlled by a family of proteins that modulate mitochondrial fusion and fission. Recent evidence indicates that mitochondrial morphology is crucial for cell physiology, as changes in mitochondrial shape have been linked to neurodegeneration, calcium signalling, lifespan and cell death. Because immune cells contain few mitochondria, these organelles have been considered to have only a marginal role in this physiological context-which is conversely well characterized from the point of view of signalling. Nevertheless, accumulating evidence shows that mitochondrial dynamics have an impact on the migration and activation of immune cells and on the innate immune response. Here, we discuss the roles of mitochondrial dynamics in cell pathophysiology and consider how studying dynamics in the context of the immune system could increase our knowledge about the role of dynamics in key signalling cascades.

Keywords
  • Animals
  • *Cell Physiological Phenomena
  • Immune System/physiology
  • Membrane Fusion/physiology
  • *Mitochondria/physiology/ultrastructure
  • Mitochondrial Membranes/metabolism
  • Mitochondrial Proteins/metabolism
  • Signal Transduction/*physiology
Citation (ISO format)
CAMPELLO, Silvia, SCORRANO, Luca. Mitochondrial shape changes: orchestrating cell pathophysiology. In: EMBO reports, 2010, vol. 11, n° 9, p. 678–684. doi: 10.1038/embor.2010.115
Main files (1)
Article
accessLevelRestricted
Identifiers
Journal ISSN1469-221X
527views
0downloads

Technical informations

Creation23/05/2012 08:44:34
First validation23/05/2012 08:44:34
Update time14/03/2023 17:32:06
Status update14/03/2023 17:32:06
Last indexation29/10/2024 19:57:04
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack