Mitochondrial shape changes: orchestrating cell pathophysiology

Article Article scientifique Article Mitochondrial shape changes: orchestrating cell pathophysiology eng 2010 author Campello Silvia 665538 author Scorrano Luca 659421 678-684 10.1038/embor.2010.115 20725092 1469-221X http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933866/pdf/embor2010115.pdf Mitochondria are highly dynamic organelles, the location, size and distribution of which are controlled by a family of proteins that modulate mitochondrial fusion and fission. Recent evidence indicates that mitochondrial morphology is crucial for cell physiology, as changes in mitochondrial shape have been linked to neurodegeneration, calcium signalling, lifespan and cell death. Because immune cells contain few mitochondria, these organelles have been considered to have only a marginal role in this physiological context-which is conversely well characterized from the point of view of signalling. Nevertheless, accumulating evidence shows that mitochondrial dynamics have an impact on the migration and activation of immune cells and on the innate immune response. Here, we discuss the roles of mitochondrial dynamics in cell pathophysiology and consider how studying dynamics in the context of the immune system could increase our knowledge about the role of dynamics in key signalling cascades. Animals *Cell Physiological Phenomena Immune System/physiology Membrane Fusion/physiology *Mitochondria/physiology/ultrastructure Mitochondrial Membranes/metabolism Mitochondrial Proteins/metabolism Signal Transduction/*physiology Dewey 612 134 Département de physiologie cellulaire et métabolisme 21C false 512 Les mitochondries dans la vie cellulaire 850 EMBO reports 11 9 fd27df52-a883-43f0-b520-1c751f02991e Article Restricted file1.pdf 617109 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

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Mitochondrial shape changes: orchestrating cell pathophysiology	EMBO reports			2010	593	0

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Campello, Silvia