en
Scientific article
English

Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections

Published inThe Journal of infectious diseases, vol. 202, no. 10, p. 1482-1485
Publication date2010
Abstract

A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.

Keywords
  • Adult
  • Aged
  • Cohort Studies
  • Enzyme-Linked Immunosorbent Assay
  • Europe/epidemiology
  • Female
  • Gene Products, gag/genetics/immunology
  • Genes, Viral/genetics
  • Great Britain/epidemiology
  • HIV Infections/blood/*virology
  • *Hiv-1
  • Hepatitis C, Chronic/blood/*virology
  • Humans
  • Interferon-gamma/blood
  • Leukemia Virus, Murine/genetics/*isolation & purification
  • Leukocytes, Mononuclear/virology
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Retroviridae Infections/blood/*epidemiology/virology
  • Risk Factors
  • Tumor Virus Infections/blood/*epidemiology/virology
  • Viral Envelope Proteins/genetics
  • Young Adult
Research group
Citation (ISO format)
BARNES, Eleanor et al. Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections. In: The Journal of infectious diseases, 2010, vol. 202, n° 10, p. 1482–1485. doi: 10.1086/657167
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0022-1899
522views
0downloads

Technical informations

Creation05/23/2012 8:44:08 AM
First validation05/23/2012 8:44:08 AM
Update time03/14/2023 5:31:38 PM
Status update03/14/2023 5:31:38 PM
Last indexation02/12/2024 8:08:34 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack