Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections

Barnes, Eleanor; Flanagan, Peter; Brown, Anthony; Robinson, Nicola; Brown, Helen; McClure, Myra; Oxenius, Annette; Collier, Jane; Weber, Jonathan; Gunthard, Huldrych F.; Hirschel, Bernard; Fidler, Sarah; Phillips, Rodney; Frater, John

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Title		Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections
Authors		Barnes, Eleanor Flanagan, Peter Brown, Anthony Robinson, Nicola Brown, Helen McClure, Myra Oxenius, Annette Collier, Jane Weber, Jonathan Gunthard, Huldrych F. Hirschel, Bernard Fidler, Sarah Phillips, Rodney Frater, John show all authors [1 - 14]
Published in		The Journal of Infectious Diseases. 2010, vol. 202, no. 10, p. 1482-1485
Abstract		A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.
Keywords		Adult — Aged — Cohort Studies — Enzyme-Linked Immunosorbent Assay — Europe/epidemiology — Female — Gene Products, gag/genetics/immunology — Genes, Viral/genetics — Great Britain/epidemiology — HIV Infections/blood/virology — Hiv-1 — Hepatitis C, Chronic/blood/virology — Humans — Interferon-gamma/blood — Leukemia Virus, Murine/genetics/isolation & purification — Leukocytes, Mononuclear/virology — Male — Middle Aged — Polymerase Chain Reaction — Retroviridae Infections/blood/epidemiology/virology — Risk Factors — Tumor Virus Infections/blood/epidemiology/virology — Viral Envelope Proteins/genetics — Young Adult
Identifiers		DOI: 10.1086/657167 PMID: 20936982
Full text		Article - Limited access to UNIGE Other version: http://jid.oxfordjournals.org/content/202/10/1482.full.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group		Unité HIV (46)
Citation (ISO format)		BARNES, Eleanor et al. Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections. In: The Journal of Infectious Diseases, 2010, vol. 202, n° 10, p. 1482-1485. https://archive-ouverte.unige.ch/unige:20760