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Title

Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections

Authors
Barnes, Eleanor
Flanagan, Peter
Brown, Anthony
Robinson, Nicola
Brown, Helen
McClure, Myra
Oxenius, Annette
Collier, Jane
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Published in Journal of Infectious Diseases. 2010, vol. 202, no. 10, p. 1482-1485
Abstract A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.
Keywords AdultAgedCohort StudiesEnzyme-Linked Immunosorbent AssayEurope/epidemiologyFemaleGene Products, gag/genetics/immunologyGenes, Viral/geneticsGreat Britain/epidemiologyHIV Infections/blood/*virology*Hiv-1Hepatitis C, Chronic/blood/*virologyHumansInterferon-gamma/bloodLeukemia Virus, Murine/genetics/*isolation & purificationLeukocytes, Mononuclear/virologyMaleMiddle AgedPolymerase Chain ReactionRetroviridae Infections/blood/*epidemiology/virologyRisk FactorsTumor Virus Infections/blood/*epidemiology/virologyViral Envelope Proteins/geneticsYoung Adult
Identifiers
PMID: 20936982
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Research group Unité HIV (46)
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BARNES, Eleanor et al. Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections. In: Journal of Infectious Diseases, 2010, vol. 202, n° 10, p. 1482-1485. https://archive-ouverte.unige.ch/unige:20760

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Deposited on : 2012-05-23

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