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Identification of TORC1 and TORC2 upstream regulators

Defense Thèse de doctorat : Univ. Genève, 2011 - Sc. 4390 - 2011/12/19
Abstract All eukaryote cells, and especially singled celled species, monitor their environment and use this information to appropriately adjust their intracellular physiology. In Saccharomyces cerevisiae AGC kinase family members appear to be a major link between environmental cues and the cell growth machinery. However, how environmental cues impinge upon Pkh1/2, TORC1 and TORC2 remains a mystery. We found that TORC1, TORC2 and Pkh1/2 are positively regulated by nutrient quantity and quality. Moreover, in a complementary, hypothesis-based approach we found that regulation of TORC2 downstream of plasma membrane stress is mediated by the Slm1/2 proteins.
Keywords RapamycinTORC2Ypk1MembraneTensionEisosomesSphingolipids
URN: urn:nbn:ch:unige-203613
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PICCOLIS, Manuele. Identification of TORC1 and TORC2 upstream regulators. Université de Genève. Thèse, 2011. https://archive-ouverte.unige.ch/unige:20361

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Deposited on : 2012-05-14

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