en
Scientific article
English

Estimated dose to the rectum and colon in prostate cancer patients treated with exclusive radiation therapy presenting a secondary colorectal malignancy

Published inClinical oncology, vol. 21, no. 9, p. 687-694
Publication date2009
Abstract

AIMS: To estimate the dose to colorectal structures after external beam radiation therapy (EBRT) delivered to prostate cancer patients who developed secondary colorectal cancers (sCRC). MATERIALS AND METHODS: Using data from a population-based cancer registry of 1134 prostate cancer patients, 11/264 (4.2%) patients treated with EBRT presented a sCRC. To evaluate the dose delivered to the colon and rectum, each individual index patient was matched with a study case and, using the index case treatment characteristics, dose calculations were carried out on the latter. RESULTS: The median maximum, mean and minimum doses delivered to the colon or rectum affected by the sCRC were 39.3 (range 0.2-66.0), 5.4 (range 0.2-41.3) and 0.6 (range 0.2-7.8) Gy, respectively. All but three sCRCs occurred outside the treatment fields. The estimated rectal doses after prostate radiation therapy were substantially higher than those delivered to non-rectal colic structures (mean dose 47.2+/-16.6 vs 9.4+/-6.4 Gy), but only one (9%) patient presented a rectal cancer. The differential mean doses given to the rectosigmoid junction and sigmoid colon, with or without sCRC, were not different. CONCLUSIONS: These data suggest that the administered dose after EBRT for prostate cancer to the colon, excluding the rectum, may be below the Gy unit in sCRC patients.

Keywords
  • Aged
  • Colon/*radiation effects
  • Colorectal Neoplasms
  • Dose-Response Relationship, Radiation
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Second Primary
  • Prostatic Neoplasms/pathology/*radiotherapy
  • Radiation Injuries/complications
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Rectum/*radiation effects
  • Registries
  • Retrospective Studies
  • Treatment Outcome
Citation (ISO format)
WEBER, Damien et al. Estimated dose to the rectum and colon in prostate cancer patients treated with exclusive radiation therapy presenting a secondary colorectal malignancy. In: Clinical oncology, 2009, vol. 21, n° 9, p. 687–694. doi: 10.1016/j.clon.2009.05.008
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0936-6555
541views
1downloads

Technical informations

Creation04/23/2012 1:32:54 PM
First validation04/23/2012 1:32:54 PM
Update time03/14/2023 5:28:24 PM
Status update03/14/2023 5:28:24 PM
Last indexation01/15/2024 11:31:54 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack