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Title

Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge

Authors
Veazey, Ronald S.
Ling, Binhua
Green, Linda C.
Ribka, Erin P.
Lifson, Jeffrey D.
Piatak, Michael Jr
Lederman, Michael M.
Mosier, Donald
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Published in The Journal of Infectious Diseases. 2009, vol. 199, no. 10, p. 1525-1527
Abstract Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.
Keywords Administration, TopicalAnimalsChemokine CCL5/administration & dosage/*therapeutic useChemokines/administration & dosage/genetics/*therapeutic useFemaleMacacaRNA, Viral/blood/geneticsRecombinant Proteins/administration & dosage/therapeutic useReverse Transcriptase Polymerase Chain ReactionSimian Acquired Immunodeficiency Syndrome/*prevention & controlVagina/*virologyViral Load
Identifiers
PMID: 19331577
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Research group HIV (835)
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VEAZEY, Ronald S. et al. Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge. In: The Journal of Infectious Diseases, 2009, vol. 199, n° 10, p. 1525-1527. https://archive-ouverte.unige.ch/unige:20148

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Deposited on : 2012-04-23

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