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Scientific article
English

Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge

Published inThe Journal of infectious diseases, vol. 199, no. 10, p. 1525-1527
Publication date2009
Abstract

Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.

Keywords
  • Administration, Topical
  • Animals
  • Chemokine CCL5/administration & dosage/*therapeutic use
  • Chemokines/administration & dosage/genetics/*therapeutic use
  • Female
  • Macaca
  • RNA, Viral/blood/genetics
  • Recombinant Proteins/administration & dosage/therapeutic use
  • Reverse Transcriptase Polymerase Chain Reaction
  • Simian Acquired Immunodeficiency Syndrome/*prevention & control
  • Vagina/*virology
  • Viral Load
Research group
Citation (ISO format)
VEAZEY, Ronald S. et al. Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge. In: The Journal of infectious diseases, 2009, vol. 199, n° 10, p. 1525–1527. doi: 10.1086/598685
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ISSN of the journal0022-1899
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