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Title

Tumors that look for their springtime in APRIL

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Published in Critical Reviews in Oncology / Hematology. 2009, vol. 72, no. 2, p. 91-97
Abstract Inflammatory cells produce a proliferation inducing ligand (APRIL), one of the most recently cloned members of the tumor necrosis factor (TNF) family. Early experiments implicated APRIL as a promoting factor in the natural course of various cancers, reinforcing the concept that host inflammatory reactions are part of a tumor development. Recent studies have further analyzed the tumor-promoting role of APRIL in patients with solid tumors or with hematological malignancies. Here, we will review the recent literature, and provide evidence that APRIL may be a useful prognostic tool and a potential target in the treatment of some cancers.
Keywords AnimalsHumansNeoplasms/*metabolismTumor Necrosis Factor Ligand Superfamily Member 13/*physiology
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PMID: 19286389
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Research groups Immunothérapie des cancers (42)
Analyses cellulaires et moléculaires des hémopathies malignes (929)
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ROOSNEK, Eddy Emile et al. Tumors that look for their springtime in APRIL. In: Critical Reviews in Oncology / Hematology, 2009, vol. 72, n° 2, p. 91-97. https://archive-ouverte.unige.ch/unige:20065

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Deposited on : 2012-04-23

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