Lung mechanical and vascular changes during positive- and negative-pressure lung inflations: importance of reference pressures in the pulmonary vasculature

Petak, Ferenc; Albu, Gergely; Lele, Eniko; Hantos, Zoltan; Morel, Denis; Fontao, Fabienne; Habre, Walid

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Title		Lung mechanical and vascular changes during positive- and negative-pressure lung inflations: importance of reference pressures in the pulmonary vasculature
Authors		Petak, Ferenc Albu, Gergely Lele, Eniko Hantos, Zoltan Morel, Denis Fontao, Fabienne Habre, Walid
Published in		Journal of Applied Physiology. 2009, vol. 106, no. 3, p. 935-942
Abstract		The continuous changes in lung mechanics were related to those in pulmonary vascular resistance (Rv) during lung inflations to clarify the mechanical changes in the bronchoalveolar system and the pulmonary vasculature. Rv and low-frequency lung impedance data (Zl) were measured continuously in isolated, perfused rat lungs during 2-min inflation-deflation maneuvers between transpulmonary pressures of 2.5 and 22 cmH(2)O, both by applying positive pressure at the trachea and by generating negative pressure around the lungs in a closed box. ZL was averaged and evaluated for 2-s time windows; airway resistance (Raw), parenchymal damping and elastance (H) were determined in each window. Lung inflation with positive and negative pressures led to very similar changes in lung mechanics, with maximum decreases in Raw [-68 +/- 4 (SE) vs. -64 +/- 18%] and maximum increases in H (379 +/- 36 vs. 348 +/- 37%). Rv, however, increased with positive inflation pressure (15 +/- 1%), whereas it exhibited mild decreases during negative-pressure expansions (-3 +/- 0.3%). These results demonstrate that pulmonary mechanical changes are not affected by the opposing modes of lung inflations and confirm the importance of relating the pulmonary vascular pressures in interpreting changes in Rv.
Keywords		Adaptation, Physiological — Airway Resistance/physiology — Animals — Elasticity/physiology — Lung/blood supply/physiology — Male — Perfusion — Pressure — Pulmonary Circulation/physiology — Rats — Rats, Sprague-Dawley — Reference Values — Respiration, Artificial/methods — Respiratory Mechanics — Vascular Resistance/*physiology
Identifiers		DOI: 10.1152/japplphysiol.00831.2007 PMID: 19112162
Full text		Article - Limited access to UNIGE Other version: http://jap.physiology.org/content/106/3/935.full.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie et soins intensifs Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research group		Enfants et hyperréactivité bronchique (69)
Citation (ISO format)		PETAK, Ferenc et al. Lung mechanical and vascular changes during positive- and negative-pressure lung inflations: importance of reference pressures in the pulmonary vasculature. In: Journal of Applied Physiology, 2009, vol. 106, n° 3, p. 935-942. https://archive-ouverte.unige.ch/unige:20029