en
Scientific article
English

Propagation of spreading depression inversely correlates with cortical myelin content

Published inAnnals of neurology, vol. 66, no. 3, p. 355-365
Publication date2009
Abstract

OBJECTIVE: Cortical myelin can be severely affected in patients with demyelinating disorders of the central nervous system. However, the functional implication of cortical demyelination remains elusive. In this study, we investigated whether cortical myelin influences cortical spreading depression (CSD). METHODS: CSD measurements were performed in rodent models of toxic and autoimmune induced cortical demyelination, in neuregulin-1 type I transgenic mice displaying cortical hypermyelination, and in glial fibrillary acidic protein-transgenic mice exhibiting pronounced astrogliosis. RESULTS: Cortical demyelination, but not astrogliosis or inflammation per se, was associated with accelerated CSD. In contrast, hypermyelinated neuregulin-1 type I transgenic mice displayed a decelerated CSD propagation. INTERPRETATION: Cortical myelin may be crucially involved in the stabilization and buffering of extracellular ion content that is decisive for CSD propagation velocity and cortical excitability, respectively. Our data thus indicate that cortical involvement in human demyelinating diseases may lead to relevant alterations of cortical function.

Keywords
  • Animals
  • Astrocytes
  • Cerebral Cortex/chemistry/drug effects/*physiopathology
  • Cortical Spreading Depression/drug effects/*physiology
  • Cuprizone/pharmacology
  • Demyelinating Diseases/chemically induced/genetics/*physiopathology
  • Electroencephalography
  • Encephalomyelitis, Autoimmune, Experimental/*physiopathology
  • Female
  • Functional Laterality/physiology
  • Glial Fibrillary Acidic Protein/genetics
  • Gliosis
  • Humans
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Multiple Sclerosis/physiopathology
  • Myelin Basic Proteins/*analysis/physiology
  • Myelin Sheath/genetics/*physiology
  • Neuregulin-1/genetics
  • Rats
  • Rats, Inbred Lew
Citation (ISO format)
MERKLER, Doron et al. Propagation of spreading depression inversely correlates with cortical myelin content. In: Annals of neurology, 2009, vol. 66, n° 3, p. 355–365. doi: 10.1002/ana.21746
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ISSN of the journal0364-5134
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