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Title

Diagnostic precision of image-guided multisampling core needle biopsy of suspected lymphomas in a primary care hospital

Authors
Copercini, M.
Published in British Journal of Cancer. 2009, vol. 100, no. 11, p. 1771-1776
Abstract We evaluated the diagnostic quality of image-guided multisampling core needle biopsy (CNB) in patients investigated for suspected lymphoma in a primary care hospital. A total of 112 patients were consecutively assessed during a 3-year period. There were 80 lymphoid site biopsies and 32 non-lymphoid site biopsies. Eight to nine cores were obtained from different parts of the biopsy site. Two cores were systematically frozen, allowing for further morphological, immunochemistry and molecular studies. The diagnostic yield of CNB for malignancy was 100%. Only 47% (41/87) of patients with initial suspicion of lymphoma were finally diagnosed with Lymphoma. The diagnostic yield of CNB for lymphoma typing was 98% (62/63), according to the WHO classification. The diagnostic yield of CNB for complete lymphoma subtyping/grading was 86% (54/63). The diagnostic yield of CNB for a definite diagnosis of benignity was only 47% (8/17). In a primary care setting, multisampling CNB is a minimally invasive, and very accurate procedure for confirming malignancy in patients with suspected lymphoma, presenting with superficial/deep-seated, lymphoid/non-lymphoid site targets. With a very high diagnostic yield for lymphoma typing and a high diagnostic yield for complete lymphoma subtyping/grading a therapeutic decision can be taken in most patients.
Keywords AdultAgedAged, 80 and overBiopsy, NeedleFemale*HospitalsHumansLymphoma/*diagnosis/*surgeryMaleMiddle Aged*Primary Health CareRecurrence
Identifiers
PMID: 19401685
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Structures
Research groups Immunothérapie des cancers (42)
Lymphomes MALT et réplication virale (807)
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(ISO format)
LOUBEYRE, Pierre et al. Diagnostic precision of image-guided multisampling core needle biopsy of suspected lymphomas in a primary care hospital. In: British Journal of Cancer, 2009, vol. 100, n° 11, p. 1771-1776. doi: 10.1038/sj.bjc.6605059 https://archive-ouverte.unige.ch/unige:19933

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Deposited on : 2012-04-23

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