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Scientific article
English

Retronasal olfactory function in Parkinson's disease

Contributors

Landis, Basile Nicolas; Cao Van, Hélène; Guinand, Nils; Horvath, Judit; Haehner, Antje; Savva, Elena; Hugentobler, Marianne; Lacroix, Jean-Sylvain; Burkhard, Pierre

Published in

The Laryngoscope, vol. 119, no. 11, p. 2280-2283

Publication date

2009

Abstract

OBJECTIVES/HYPOTHESIS: Orthonasal olfaction is severely altered in PD patients. Retronasal olfactory function has been shown to be preserved under certain conditions even in the absence of orthonasal function. This study was undertaken to investigate retronasal versus orthonasal olfactory function in Parkinson's disease (PD). STUDY DESIGN: Prospective study. METHODS: A total of 45 PD patients (mean age, 61 years; range 26-82 years) underwent orthonasal olfactory testing with a standardized olfactory test (Sniffin' Sticks) and retronasal olfactory testing with a 10-item identification kit based on aromatized powders. RESULTS: Regarding orthonasal tests, all PD patients scored within the range of hyposmia and functional anosmia. The mean correct orthonasal identification score for PD patients was 56% +/- 2.6%, and the mean retronasal identification rate was 60% +/- 3%. There was no significant difference between ortho- and retronasal odor identification (P = .15). CONCLUSIONS: The present study shows that retronasal and orthonasal olfactory function are severely impaired in PD patients, and this impairment is of similar magnitude for both functions. The contribution of this finding to the food-intake behavior of PD patients is discussed.

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nasal Cavity/physiopathology
  • Parkinson Disease/*physiopathology
  • Prospective Studies
  • *Smell

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

LANDIS, Basile Nicolas et al. Retronasal olfactory function in Parkinson’s disease. In: The Laryngoscope, 2009, vol. 119, n° 11, p. 2280–2283. doi: 10.1002/lary.20547

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Additional URL for this publication

http://onlinelibrary.wiley.com/store/10.1002/lary.20547/asset/20547_ftp.pdf?v=1&t=gzs4lvs8&s=0d81e847069e71639a75e8d7be01f158116d2806

Journal ISSN

0023-852X
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Technical informations

Creation

23/04/2012 13:24:05

First validation

23/04/2012 13:24:05

Update

14/03/2023 17:25:45

Status update

14/03/2023 17:25:44

Last indexation

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