Scientific article

Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus

Published inDiabetes & metabolism, vol. 34, no. 1, p. 75-81
Publication date2008

Adipose tissue secretes a variety of cytokines, some of which are increased in the serum of obese patients. The anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra) is the most highly elevated known cytokine in human obesity, and its serum levels are strongly associated with the degree of insulin resistance in non-diabetic patients. AIM: The present study examined serum levels of IL-1Ra in type 2 diabetic patients (T2DM) and their relationships with three other adipokines (leptin, interleukin-6 [IL-6], adiponectin). Their correlation with anthropometric and biochemical variables was examined, as well as their intraindividual fluctuations. METHODS: Fifty T2DM patients, aged 58+/-13 years, were consecutively recruited among those electively hospitalized for a one-week intensive training course with our Diabetes Education Service. Anthropometric measurements and blood samples were taken after an overnight fast on admission (baseline) and after four days. RESULTS: Mean serum levels of IL-1Ra and leptin, but not of IL-6 and adiponectin, were significantly higher in women than in men (P<0.0006), and this difference persisted after correction for body mass index (BMI) (P<0.0004). In addition, IL-1Ra and leptin were strongly correlated with the BMI (P<0.0004). By contrast, no significant correlations were observed between IL-1Ra and glucose-control parameters. Finally, all four adipokines exhibited wide interindividual variability, but with limited intraindividual fluctuations over the short time period. CONCLUSION: IL-1Ra, leptin and adiponectin serum levels exhibit marked interindividual variation with high intraindividual consistency. A gender-based dimorphic pattern for IL-1Ra, independent of the degree of adiposity and glucose control, was also found.

  • Adiponectin/blood
  • Adult
  • Aged
  • Aged, 80 and over
  • Body Weight
  • Diabetes Mellitus, Type 2/blood
  • Female
  • Hemoglobin A, Glycosylated/analysis
  • Humans
  • Interleukin 1 Receptor Antagonist Protein/blood
  • Leptin/blood
  • Male
  • Middle Aged
  • Patient Selection
  • Sex Characteristics
Citation (ISO format)
YBARRA, J. et al. Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus. In: Diabetes & metabolism, 2008, vol. 34, n° 1, p. 75–81. doi: 10.1016/j.diabet.2007.10.006
Main files (1)
Article (Accepted version)
ISSN of the journal1262-3636

Technical informations

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