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Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus

Ybarra, J.
Published in Diabetes & metabolism. 2008, vol. 34, no. 1, p. 75-81
Abstract Adipose tissue secretes a variety of cytokines, some of which are increased in the serum of obese patients. The anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra) is the most highly elevated known cytokine in human obesity, and its serum levels are strongly associated with the degree of insulin resistance in non-diabetic patients. AIM: The present study examined serum levels of IL-1Ra in type 2 diabetic patients (T2DM) and their relationships with three other adipokines (leptin, interleukin-6 [IL-6], adiponectin). Their correlation with anthropometric and biochemical variables was examined, as well as their intraindividual fluctuations. METHODS: Fifty T2DM patients, aged 58+/-13 years, were consecutively recruited among those electively hospitalized for a one-week intensive training course with our Diabetes Education Service. Anthropometric measurements and blood samples were taken after an overnight fast on admission (baseline) and after four days. RESULTS: Mean serum levels of IL-1Ra and leptin, but not of IL-6 and adiponectin, were significantly higher in women than in men (P<0.0006), and this difference persisted after correction for body mass index (BMI) (P<0.0004). In addition, IL-1Ra and leptin were strongly correlated with the BMI (P<0.0004). By contrast, no significant correlations were observed between IL-1Ra and glucose-control parameters. Finally, all four adipokines exhibited wide interindividual variability, but with limited intraindividual fluctuations over the short time period. CONCLUSION: IL-1Ra, leptin and adiponectin serum levels exhibit marked interindividual variation with high intraindividual consistency. A gender-based dimorphic pattern for IL-1Ra, independent of the degree of adiposity and glucose control, was also found.
Keywords Adiponectin/bloodAdultAgedAged, 80 and overBody WeightDiabetes Mellitus, Type 2/bloodFemaleHemoglobin A, Glycosylated/analysisHumansInterleukin 1 Receptor Antagonist Protein/bloodLeptin/bloodMaleMiddle AgedPatient SelectionSex Characteristics
PMID: 18243027
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Research groups Education thérapeutique du patient, diabète et obésité (600)
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YBARRA, J. et al. Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus. In: Diabetes & metabolism, 2008, vol. 34, n° 1, p. 75-81. doi: 10.1016/j.diabet.2007.10.006 https://archive-ouverte.unige.ch/unige:1938

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Deposited on : 2009-06-10

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