Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus

Article Article scientifique Article Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus eng 2008 author Ybarra J. author Lehmann Thalia 84385 author Golay Alain 27404 author Juge Cristiana Enrica 22166 author Roux-Lombard Pascale 22481 author Dayer Jean-Michel 25468 author Meier Christoph 28951 75-81 10.1016/j.diabet.2007.10.006 18243027 1262-3636 Adipose tissue secretes a variety of cytokines, some of which are increased in the serum of obese patients. The anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra) is the most highly elevated known cytokine in human obesity, and its serum levels are strongly associated with the degree of insulin resistance in non-diabetic patients. AIM: The present study examined serum levels of IL-1Ra in type 2 diabetic patients (T2DM) and their relationships with three other adipokines (leptin, interleukin-6 [IL-6], adiponectin). Their correlation with anthropometric and biochemical variables was examined, as well as their intraindividual fluctuations. METHODS: Fifty T2DM patients, aged 58+/-13 years, were consecutively recruited among those electively hospitalized for a one-week intensive training course with our Diabetes Education Service. Anthropometric measurements and blood samples were taken after an overnight fast on admission (baseline) and after four days. RESULTS: Mean serum levels of IL-1Ra and leptin, but not of IL-6 and adiponectin, were significantly higher in women than in men (P<0.0006), and this difference persisted after correction for body mass index (BMI) (P<0.0004). In addition, IL-1Ra and leptin were strongly correlated with the BMI (P<0.0004). By contrast, no significant correlations were observed between IL-1Ra and glucose-control parameters. Finally, all four adipokines exhibited wide interindividual variability, but with limited intraindividual fluctuations over the short time period. CONCLUSION: IL-1Ra, leptin and adiponectin serum levels exhibit marked interindividual variation with high intraindividual consistency. A gender-based dimorphic pattern for IL-1Ra, independent of the degree of adiposity and glucose control, was also found. Adiponectin/blood Adult Aged Aged, 80 and over Body Weight Diabetes Mellitus, Type 2/blood Female Hemoglobin A, Glycosylated/analysis Humans Interleukin 1 Receptor Antagonist Protein/blood Leptin/blood Male Middle Aged Patient Selection Sex Characteristics Dewey 613 Dewey 616 56 Département de médecine 221 66 Institut de santé globale 22A1 false 334 Education thérapeutique du patient, diabète et obésité 600 449 Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles 779 Diabetes & metabolism 34 1 196300b9-0011-4c74-a4ba-9d6edbb6bf8c Article (Accepted version) Restricted Article.pdf 481775 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de santé globale

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Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus	Diabetes & metabolism			2008	674	0

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Lehmann, Thalia