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Aggravation of viral hepatitis by platelet-derived serotonin

Lang, Philipp A.
Contaldo, Claudio
Georgiev, Panco
El-Badry, Ashraf Mohammad
Recher, Mike
Kurrer, Michael
Cervantes-Barragan, Luisa
Ludewig, Burkhard
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Published in Nature medicine. 2008, vol. 14, no. 7, p. 756-761
Abstract More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in liver steatosis, liver cirrhosis, end-stage liver failure or hepatocellular carcinoma. Virus-specific T cells are a major determinant of the outcome of hepatitis, as they contribute to the early control of chronic hepatitis viruses, but they also mediate immunopathology during persistent virus infection. We have analyzed the role of platelet-derived vasoactive serotonin during virus-induced CD8(+) T cell-dependent immunopathological hepatitis in mice infected with the noncytopathic lymphocytic choriomeningitis virus. After virus infection, platelets were recruited to the liver, and their activation correlated with severely reduced sinusoidal microcirculation, delayed virus elimination and increased immunopathological liver cell damage. Lack of platelet-derived serotonin in serotonin-deficient mice normalized hepatic microcirculatory dysfunction, accelerated virus clearance in the liver and reduced CD8(+) T cell-dependent liver cell damage. In keeping with these observations, serotonin treatment of infected mice delayed entry of activated CD8(+) T cells into the liver, delayed virus control and aggravated immunopathological hepatitis. Thus, vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology.
Keywords AnimalsBlood Platelets/*chemistryCD8-Positive T-Lymphocytes/metabolismHalf-LifeHepatitis, Viral, Animal/immunology/*pathology/virologyLiver/blood supply/immunology/pathologyLymphocytic Choriomeningitis/*pathologyMiceMice, Inbred C57BLMice, KnockoutMicrocirculationPlatelet CountSerotonin/*deficiency/genetics/*metabolism
PMID: 18516052
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Other version: http://www.nature.com/nm/journal/v14/n7/pdf/nm1780.pdf
Research group La Sclérose en plaques (908)
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LANG, Philipp A. et al. Aggravation of viral hepatitis by platelet-derived serotonin. In: Nature Medicine, 2008, vol. 14, n° 7, p. 756-761. doi: 10.1038/nm1780 https://archive-ouverte.unige.ch/unige:19180

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Deposited on : 2012-03-27

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