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Large-scale population study of human cell lines indicates that dosage compensation is virtually complete
|Published in||PLOS Genetics. 2008, vol. 4, no. 1, p. e9|
|Abstract||X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.|
|Keywords||Cell Line — Chromosomes, Human, X — Chromosomes, Human, Y — *Dosage Compensation, Genetic — Female — Gene Expression — Genes, X-Linked — *Genetics, Population — Haplotypes — Heterozygote — Humans — Lymphocytes/*cytology — Male — Oligonucleotide Array Sequence Analysis — Polymorphism, Single Nucleotide — X Chromosome Inactivation|
|Research group||Population Genomics and Genetics of Complex Traits (892)|
|JOHNSTON, Colette M. et al. Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. In: PLOS Genetics, 2008, vol. 4, n° 1, p. e9. https://archive-ouverte.unige.ch/unige:19017|