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Title

Large-scale population study of human cell lines indicates that dosage compensation is virtually complete

Authors
Johnston, Colette M.
Lovell, Frances L.
Leongamornlert, Daniel A.
Stranger, Barbara E.
Ross, Mark T.
Published in PLOS Genetics. 2008, vol. 4, no. 1, p. e9
Abstract X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.
Keywords Cell LineChromosomes, Human, XChromosomes, Human, Y*Dosage Compensation, GeneticFemaleGene ExpressionGenes, X-Linked*Genetics, PopulationHaplotypesHeterozygoteHumansLymphocytes/*cytologyMaleOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideX Chromosome Inactivation
Identifiers
PMID: 18208332
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Research group Population Genomics and Genetics of Complex Traits (892)
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JOHNSTON, Colette M. et al. Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. In: PLOS Genetics, 2008, vol. 4, n° 1, p. e9. https://archive-ouverte.unige.ch/unige:19017

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Deposited on : 2012-03-27

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