Mitochondrial control of macrophage polarity in tumors

Kiss, Mate; Pittet, Mikaël

doi:10.1016/j.immuni.2025.06.008

Scientific article

English

Mitochondrial control of macrophage polarity in tumors

ContributorsKiss, Mate; Pittet, Mikaël

Published inImmunity, vol. 58, no. 7, p. 1618-1620

Publication date2025-07-08

Abstract

Macrophages can foster pro- or anti-tumor immune environments. In this issue of Immunity, Clark et al. report that altering the composition of the mitochondrial electron transport chain reprograms macrophages toward a CXCL9^hi SPP1^lo immunostimulatory phenotype, thus amplifying anti-tumor immunity.

Keywords

Animals
Cell Polarity / immunology
Humans
Macrophages / immunology
Macrophages / metabolism
Mice
Mitochondria / immunology
Mitochondria / metabolism
Neoplasms / immunology
Neoplasms / metabolism
Tumor Microenvironment / immunology

Affiliation entities

Research groups

Comprendre et manipuler le système immunitaire pour lutter contre le cancer (1024)

Citation (ISO format)

KISS, Mate, PITTET, Mikaël. Mitochondrial control of macrophage polarity in tumors. In: Immunity, 2025, vol. 58, n° 7, p. 1618–1620. doi: 10.1016/j.immuni.2025.06.008

Article (Published version)

Identifiers

PID : unige:189485
DOI : 10.1016/j.immuni.2025.06.008
PMID : 40633525

Additional URL for this publicationhttps://www.sciencedirect.com/science/article/pii/S1074761325002778

Journal ISSN1074-7613

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Creation10/10/2025 13:00:10

First validation08/12/2025 15:46:25

Update08/12/2025 15:47:27

Status update08/12/2025 15:47:27

Last indexation08/12/2025 15:47:28

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Mitochondrial control of macrophage polarity in tumors

Macrophages can foster pro- or anti-tumor immune environments. In this issue of Immunity, Clark et al. report that altering the composition of the mitochondrial electron transport chain reprograms macrophages toward a CXCL9hi SPP1lo immunostimulatory phenotype, thus amplifying anti-tumor immunity.

Technical informations