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Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts

Rohde, Kyle H
Russell, David G
Published in Science. 2009, vol. 323, no. 5922, p. 1729-33
Abstract To generate efficient vaccines and cures for Mycobacterium tuberculosis, we need a far better understanding of its modes of infection, persistence, and spreading. Host cell entry and the establishment of a replication niche are well understood, but little is known about how tubercular mycobacteria exit host cells and disseminate the infection. Using the social amoeba Dictyostelium as a genetically tractable host for pathogenic mycobacteria, we discovered that M. tuberculosis and M. marinum, but not M. avium, are ejected from the cell through an actin-based structure, the ejectosome. This conserved nonlytic spreading mechanism requires a cytoskeleton regulator from the host and an intact mycobacterial ESX-1 secretion system. This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells.
Keywords Actins/physiologyAnimalsBacterial Proteins/metabolismCell Membrane/microbiologyCytoskeleton/microbiology/physiology/ultrastructureCytosol/microbiologyDictyostelium/microbiology/ultrastructureGTP Phosphohydrolases/metabolismMycobacterium avium/genetics/pathogenicity/physiologyMycobacterium marinum/genetics/pathogenicity/physiologyMycobacterium tuberculosis/genetics/pathogenicity/physiologyPhagocytosisPressureVacuoles/microbiology
PMID: 19325115
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HAGEDORN, Monica et al. Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts. In: Science, 2009, vol. 323, n° 5922, p. 1729-33. doi: 10.1126/science.1169381 https://archive-ouverte.unige.ch/unige:18878

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Deposited on : 2012-03-19

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