Scientific article
Open access

Mucolipin controls lysosome exocytosis in Dictyostelium

Published inJournal of cell science, vol. 125, no. 9, p. 2315-2322
Publication date2012

Mucolipidosis type IV is a still poorly understood lysosomal storage disease caused by alterations in the mucolipin lysosomal calcium channel. In this study, we generated mucolipin knockout Dictyostelium cells, and observed that lysosome exocytosis was markedly increased in these cells compared to wild-type cells. In addition, mucolipin KO cells were more resistant to calcium deprivation, and the calcium concentration in their secretory lysosomes was decreased, suggesting that mucolipin transfers calcium ions from the cytosol to the lumen of secretory lysosomes. We speculate that mucolipin attenuates the fusogenic effect of local cytosolic calcium increases by dissipating them into the lumen of lysosomal compartments.

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Citation (ISO format)
LIMA, Wanessa Cristina et al. Mucolipin controls lysosome exocytosis in Dictyostelium. In: Journal of cell science, 2012, vol. 125, n° 9, p. 2315–2322. doi: 10.1242/jcs.100362
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Article (Published version)
ISSN of the journal0021-9533

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