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Title

Mucolipin controls lysosome exocytosis in Dictyostelium
Authors
Lima, Wanessa C
Leuba, Florence
Soldati, Thierry
Cosson, Pierre
Published in Journal of Cell Science. 2012, vol. 125, no. 9, p. 2315-2322
Abstract Mucolipidosis type IV is a still poorly understood lysosomal storage disease caused by alterations in the mucolipin lysosomal calcium channel. In this study, we generated mucolipin knockout Dictyostelium cells, and observed that lysosome exocytosis was markedly increased in these cells compared to wild-type cells. In addition, mucolipin KO cells were more resistant to calcium deprivation, and the calcium concentration in their secretory lysosomes was decreased, suggesting that mucolipin transfers calcium ions from the cytosol to the lumen of secretory lysosomes. We speculate that mucolipin attenuates the fusogenic effect of local cytosolic calcium increases by dissipating them into the lumen of lysosomal compartments.
Identifiers
PMID: 22357942
Full text
Article (Published version) (1.4 MB) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Faculté des sciences / Section de chimie et biochimie / Département de biochimie
Research group Phagocytose (140)
Citation
(ISO format) 		LIMA, Wanessa C et al. Mucolipin controls lysosome exocytosis in Dictyostelium. In: Journal of Cell Science, 2012, vol. 125, n° 9, p. 2315-2322. https://archive-ouverte.unige.ch/unige:18871

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Deposited on : 2012-03-19

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