UNIGE document Scientific Article
previous document  unige:18871  next document
add to browser collection

Mucolipin controls lysosome exocytosis in Dictyostelium

Published in Journal of cell science. 2012, vol. 125, no. 9, p. 2315-2322
Abstract Mucolipidosis type IV is a still poorly understood lysosomal storage disease caused by alterations in the mucolipin lysosomal calcium channel. In this study, we generated mucolipin knockout Dictyostelium cells, and observed that lysosome exocytosis was markedly increased in these cells compared to wild-type cells. In addition, mucolipin KO cells were more resistant to calcium deprivation, and the calcium concentration in their secretory lysosomes was decreased, suggesting that mucolipin transfers calcium ions from the cytosol to the lumen of secretory lysosomes. We speculate that mucolipin attenuates the fusogenic effect of local cytosolic calcium increases by dissipating them into the lumen of lysosomal compartments.
PMID: 22357942
Full text
Article (Published version) (1.4 MB) - public document Free access
Research group Phagocytose (140)
(ISO format)
LIMA, Wanessa Cristina et al. Mucolipin controls lysosome exocytosis in Dictyostelium. In: Journal of cell science, 2012, vol. 125, n° 9, p. 2315-2322. doi: 10.1242/jcs.100362 https://archive-ouverte.unige.ch/unige:18871

489 hits



Deposited on : 2012-03-19

Export document
Format :
Citation style :