Mucolipin controls lysosome exocytosis in Dictyostelium

Lima, Wanessa Cristina; Leuba, Florence; Soldati, Thierry; Cosson, Pierre

doi:10.1242/jcs.100362

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Title		Mucolipin controls lysosome exocytosis in Dictyostelium
Authors		Lima, Wanessa Cristina Leuba, Florence Soldati, Thierry Cosson, Pierre
Published in		Journal of Cell Science. 2012, vol. 125, no. 9, p. 2315-2322
Abstract		Mucolipidosis type IV is a still poorly understood lysosomal storage disease caused by alterations in the mucolipin lysosomal calcium channel. In this study, we generated mucolipin knockout Dictyostelium cells, and observed that lysosome exocytosis was markedly increased in these cells compared to wild-type cells. In addition, mucolipin KO cells were more resistant to calcium deprivation, and the calcium concentration in their secretory lysosomes was decreased, suggesting that mucolipin transfers calcium ions from the cytosol to the lumen of secretory lysosomes. We speculate that mucolipin attenuates the fusogenic effect of local cytosolic calcium increases by dissipating them into the lumen of lysosomal compartments.
Identifiers		DOI: 10.1242/jcs.100362 PMID: 22357942
Full text		Article (Published version) (1.4 MB) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme Faculté des sciences / Section de chimie et biochimie / Département de biochimie
Research group		Phagocytose (140)
Citation (ISO format)		LIMA, Wanessa Cristina et al. Mucolipin controls lysosome exocytosis in Dictyostelium. In: Journal of Cell Science, 2012, vol. 125, n° 9, p. 2315-2322. doi: 10.1242/jcs.100362 https://archive-ouverte.unige.ch/unige:18871