Scientific article
OA Policy
English

Mucolipin controls lysosome exocytosis in Dictyostelium

Published inJournal of cell science, vol. 125, no. 9, p. 2315-2322
Publication date2012
Abstract

Mucolipidosis type IV is a still poorly understood lysosomal storage disease caused by alterations in the mucolipin lysosomal calcium channel. In this study, we generated mucolipin knockout Dictyostelium cells, and observed that lysosome exocytosis was markedly increased in these cells compared to wild-type cells. In addition, mucolipin KO cells were more resistant to calcium deprivation, and the calcium concentration in their secretory lysosomes was decreased, suggesting that mucolipin transfers calcium ions from the cytosol to the lumen of secretory lysosomes. We speculate that mucolipin attenuates the fusogenic effect of local cytosolic calcium increases by dissipating them into the lumen of lysosomal compartments.

Research groups
Citation (ISO format)
LIMA, Wanessa Cristina et al. Mucolipin controls lysosome exocytosis in Dictyostelium. In: Journal of cell science, 2012, vol. 125, n° 9, p. 2315–2322. doi: 10.1242/jcs.100362
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0021-9533
605views
342downloads

Technical informations

Creation19/03/2012 15:46:00
First validation19/03/2012 15:46:00
Update time14/03/2023 17:09:52
Status update14/03/2023 17:09:52
Last indexation10/12/2024 11:38:19
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack