Switzerland's vaccination guidelines are regularly updated, recent key changes involve vaccines for COVID-19, pneumococcus, respiratory syncytial virus, influenza, shingles, mpox, and tick-borne encephalitis. In the context of weakening public health policies, these updates highlights the importance of maintaining high vaccine coverage, especially among at-risk groups. General practitioners play a central role in reviewing vaccination status, informing patients, and addressing vaccine hesitancy through empathetic, motivational communication. Improving digital tools and ensuring data privacy are strategic priorities to improve vaccine uptake and meet today's public health challenges.