The aim of the present study was to compare BPD patients with healthy controls on the score of single nucleotid polymorphisms (rs2030324, rs988748, rs6265, rs7124442) and length polymorphisms (BDNF-LCPR and BDNF microsatellite) on the BNDF gene. Furthermore, BDNF methylations levels (BDNF promoter 4 and BDNF 81B) should be compared between the two groups. An additionally goal was to assess the effect of I-DBT on methylation levels at the BDNF gene.