Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene

Article Article scientifique Article Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene eng 2013-01-15 2013-01 author Perroud Nader Ali 0000-0002-9282-9216 94458 author Salzmann Annick 0000-0003-0571-251X 510521 author Prada Paco Boris 506849 author Nicastro Rosetta 58466 author Hoeppli Puathy Marie-Eve 595289 author Furrer Sandra 729732 author Ardu Stefano 506446 author Krejci Ivo 122923 author Karege Félicien 61553 author Malafosse Alain 111681 e207 10.1038/tp.2012.140 23422958 2158-3188 PMC3566720 https://www.nature.com/articles/tp2012140 Downregulation of brain-derived neurotrophic factor (BDNF) gene expression with corresponding increased methylation at specific promoters has been associated with stressful experiences in early life and may explain later adulthood psychopathology. We measured the percentage of methylation at BDNF CpG exons I and IV as well as plasma BDNF protein levels in 115 subjects with borderline personality disorder (BPD) and 52 controls. BPD subjects then underwent a 4-week course of intensive dialectical behavior therapy (I-DBT). BDNF methylation status and protein levels were re-assessed at the end of treatment. BPD subjects had significantly higher methylation status in both CpG regions than controls. In addition, the higher the number of childhood trauma, the higher was the methylation status. In BPD subjects, BDNF methylation significantly increased after I-DBT. Nonresponders accounted for the majority of this increase, whereas responders showed a decrease in methylation status over time. Accordingly, the changes in methylation status over time were significantly associated with changes in depression scores, hopelessness scores and impulsivity. No association was found between protein levels and BDNF methylation status. We here found a relationship between child maltreatment and higher DNA methylation of BDNF. These results moreover support the idea that these epigenetic marks may be changed through psychotherapeutic approaches and that these changes underline changes in cognitive functions. Adult Borderline Personality Disorder / genetics Borderline Personality Disorder / therapy Brain-Derived Neurotrophic Factor / antagonists & inhibitors Brain-Derived Neurotrophic Factor / genetics Brain-Derived Neurotrophic Factor / metabolism Child Abuse / classification Child Abuse / psychology Child, Preschool CpG Islands / genetics DNA Methylation / genetics Down-Regulation / genetics Female Humans Male Middle Aged Psychiatric Status Rating Scales Psychotherapy / methods Treatment Outcome Dewey 617.6 Dewey 616.89 Dewey 616 60 Département de psychiatrie 225 205 Division de cariologie et d'endodontie 24P1 56 Département de médecine 221 false 1342 Régulation des émotions : TDAH et trouble de la personnalité borderline 1028 189 Groupe Krejci Ivo (médecine dentaire) 240 Translational psychiatry 3 1 2802eec2-bec2-4b87-bac5-033dc595479b Article (Published version) Public Article-scientifique-from-unpaywall.pdf 308726 application/pdf CC BY-NC-ND-3.0 1f8b349b-e595-48f8-bdf6-73e8bca85bcd Appendix Public tp2012140x1.doc 158208 application/msword openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine dentaire / Département de médecine dentaire préventive et de premier recours / Division de cariologie et d'endodontie Faculté de médecine / Section de médecine clinique / Département de médecine

Title	Published in	Year	Views	Downloads

Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene	Translational psychiatry	2013	259	240
Genetic & epigenetic differences between borderline personality disorder patients & healthy controls		2012	819	1,350

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Furrer, Sandra