UNIGE document Doctoral Thesis
previous document  unige:18573  next document
add to browser collection
Title

Long term amelioration of established collagen-induced arthritis achieved with short term therapy combining anti-CD3 and anti-TNF treatments

Author
Directors
Dean, Yann
Defense Thèse de doctorat : Univ. Genève, 2012 - Sc. 4401 - 2012/01/26
Abstract Treating autoimmune disorders is an escalating medical and social challenge in our community. As about 1% of the world's population is afflicted by rheumatoid arthritis (RA), there is an urgent need for better therapies which originate from conducting relevant experiments in the laboratory before translating into clinical trials. Currently, there is no known cure for RA. However, early medical intervention has been shown to be important in improving outcomes with drugs such as anti-TNFs. As T cells are thought to play an important role in the initiation of RA, we hypothesized that early targeting of both TNF and T cells would result in better outcomes. The aim of this thesis was to examine the efficacy of combining anti-CD3 and anti-TNF therapies in experimental RA. Taken together, the results demonstrate a synergy when combining these treatments, providing a longer term relief from inflammation and disease progression than of either monotherapy.
Keywords Rheumatoid ArthritisT cellsAnti-CD3Anti-TNFCombitherapy
Identifiers
URN: urn:nbn:ch:unige-185732
Full text
Thesis (6 MB) - public document Free access
Structures
Citation
(ISO format)
DEPIS, Fabien. Long term amelioration of established collagen-induced arthritis achieved with short term therapy combining anti-CD3 and anti-TNF treatments. Université de Genève. Thèse, 2012. https://archive-ouverte.unige.ch/unige:18573

300 hits

262 downloads

Update

Deposited on : 2012-02-29

Export document
Format :
Citation style :