• Home
  1. Home
  2. Long term amelioration of established collagen-induced arthritis achieved with short term therapy combining anti-CD3 and anti-TNF treatments
Doctoral thesis
OA Policy
English

Long term amelioration of established collagen-induced arthritis achieved with short term therapy combining anti-CD3 and anti-TNF treatments

Contributors

Depis, Fabien

Directors

Reith, Walter; Rodriguez, Ivan; Dean, Yann

Defense date

2012-01-26

Abstract

Treating autoimmune disorders is an escalating medical and social challenge in our community. As about 1% of the world's population is afflicted by rheumatoid arthritis (RA), there is an urgent need for better therapies which originate from conducting relevant experiments in the laboratory before translating into clinical trials. Currently, there is no known cure for RA. However, early medical intervention has been shown to be important in improving outcomes with drugs such as anti-TNFs. As T cells are thought to play an important role in the initiation of RA, we hypothesized that early targeting of both TNF and T cells would result in better outcomes. The aim of this thesis was to examine the efficacy of combining anti-CD3 and anti-TNF therapies in experimental RA. Taken together, the results demonstrate a synergy when combining these treatments, providing a longer term relief from inflammation and disease progression than of either monotherapy.

Keywords

  • Rheumatoid Arthritis
  • T cells
  • Anti-CD3
  • Anti-TNF
  • Combitherapy

UNIGE affiliation entities

Citation (ISO format)

DEPIS, Fabien. Long term amelioration of established collagen-induced arthritis achieved with short term therapy combining anti-CD3 and anti-TNF treatments. Doctoral Thesis, 2012. doi: 10.13097/archive-ouverte/unige:18573

Main files (1)

Thesis

Identifiers

986views
699downloads

Technical informations

Creation

29/02/2012 11:01:00

First validation

29/02/2012 11:01:00

Update

14/03/2023 17:09:05

Status update

14/03/2023 17:09:05

Last indexation

13/05/2025 15:59:47
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated