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Contrasting patterns of nuclear and mtDNA diversity in Native American populations

Yang, Ning Ning
Mazières, Stephane
Bravi, Claudio
Wang, Sijia
Burley, Mari-Wyn
Bedoya, Gabriel
Rojas, Winston
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Published in Annals of human genetics. 2010, vol. 74, no. 6, p. 525-38
Abstract We report an integrated analysis of nuclear (autosomal, X- and Y-chromosome) short tandem repeat (STR) data and mtDNA D-loop sequences obtained in the same set of 22 Native populations from across the Americas. A north to south gradient of decreasing population diversity was observed, in agreement with a settlement of the Americas from the extreme northwest of the continent. This correlation is stronger with "least cost distances," which consider the coasts as facilitators of migration. Continent-wide estimates of population structure are highest for the Y-chromosome and lowest for the autosomes, consistent with the effective size of the different marker systems examined. Population differentiation is highest in East South America and lowest in Meso America and the Andean region. Regional analyses suggest a deviation from mutation-drift equilibrium consistent with population expansion in Meso America and the Andes and population contraction in Northwest and East South America. These data hint at an early divergence of Andean and non-Andean South Americans and at a contrasting demographic history for populations from these regions.
Keywords Chromosomes, Human, X/geneticsChromosomes, Human, Y/geneticsDNA, Mitochondrial/geneticsEmigration and ImmigrationFemaleHumansIndians, North American/geneticsIndians, South American/geneticsMaleMicrosatellite RepeatsSequence Analysis, DNA/methods
PMID: 20887376
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Research groups Envirospace Lab
ISE Biodiversité
ISE Pôle Informatique environnementale
ISE Pôle Sciences
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YANG, Ning Ning et al. Contrasting patterns of nuclear and mtDNA diversity in Native American populations. In: Annals of human genetics, 2010, vol. 74, n° 6, p. 525-38. doi: 10.1111/j.1469-1809.2010.00608.x https://archive-ouverte.unige.ch/unige:18357

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Deposited on : 2012-02-09

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