The effect of COVID-19 lockdowns on the shift from in-person (offline) social interactions to online interactions and its consequences on social support and stress attracted scholarly attention. However, much less is known about how individuals’ prior mobility experiences have influenced coping with this shift. In the present research, we hypothesized that people with mobility experiences should already be more familiar with, and could profit more from, online social interactions before the pandemic, which might buffer against the negative impact of the pandemic on the emotional social support they obtained and the stress they felt during these interactions. In order to investigate this issue, we collected data ( N = 875) in Germany during the lockdown between April and May 2021. We measured mobility by introducing a novel approach that encompasses the act of moving houses (both within a country and internationally), commuting patterns, and nationality (migration background). Participants also reported the frequency of their online and offline interactions (before and during the lockdown), as well as the emotional support they obtained from online and offline interactions and the stress felt during lockdown interactions (as compared to before the lockdown). Results provide quantitative evidence in support of the main hypothesis especially regarding migration background. We discuss the relevance of these findings for research on migration and mobility.