Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles

Loosli, Frédéric; Alonso, David; Grassi, David; Zaffalon, Pierre Léonard; Favarger, France; Zumbuehl, Andréas

doi:10.1039/c2cc16827h

Scientific article

English

Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles

ContributorsLoosli, Frédéric; Alonso, David; Grassi, David; Zaffalon, Pierre Léonard; Favarger, France; Zumbuehl, Andréas

Published inChemical communications, vol. 48, no. 10, p. 1604-1606

Publication date2012

Abstract

Two complementary artificial diether phospholipids were synthesized that can undergo a Cu(I)-catalyzed Huisgen–Sharpless click reaction. The resulting lipid can bridge the membranes of large unilamellar vesicles and cause their aggregation and ultimately their fusion.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

LOOSLI, Frédéric et al. Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles. In: Chemical communications, 2012, vol. 48, n° 10, p. 1604–1606. doi: 10.1039/c2cc16827h

Article (Published version)

Identifiers

PID : unige:18071
DOI : 10.1039/c2cc16827h

Commercial URLhttp://xlink.rsc.org/?DOI=c2cc16827h

Journal ISSN1359-7345

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Creation01/11/2012 4:23:00 PM

First validation01/11/2012 4:23:00 PM

Update time03/14/2023 5:06:49 PM

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Clickosomes—using triazole-linked phospholipid connectors to fuse vesicles

Two complementary artificial diether phospholipids were synthesized that can undergo a Cu(I)-catalyzed Huisgen–Sharpless click reaction. The resulting lipid can bridge the membranes of large unilamellar vesicles and cause their aggregation and ultimately their fusion.

Technical informations