Humor is a complex and multi-faceted phenomenon composed of a variety of cognitive, social, and emotional processes. This paper will discuss humor appreciation in individuals with autism spectrum disorder (ASD) and individuals with Williams syndrome (WS), a rare genetic disorder mainly characterized by intellectual disabilities, high social approach tendencies and high positive emotions. Drawing on research on the comprehension and appreciation of humor in individuals with ASD, this paper aims to better understand how the particular cognitive, social, and emotional profile of individuals with WS might affect their appreciation of humor and how such research could ultimately lead to a greater understanding of the nature of humor.