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Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties

Published inCurrent opinion in structural biology, vol. 26, p. 113-120
Publication date2014-06
First online date2014-06-02
Abstract

Hetero-oligomeric protein complexes are involved in many of the key processes in cells. Given that the subunits of a complex function together, it has often been expected to find that (i) they are expressed at similar levels in cells; (ii) they are simultaneously present or absent in genomes; and that (iii) the effects on fitness of deleting their genes should be similar. Such a coherence is, however, often found to be weak or absent. Multi-functionality of subunits and mechanisms of complex assembly are discussed as possible sources for the lack of coherence.

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Affiliation Not a UNIGE publication
Citation (ISO format)
MATALON, Or, HOROVITZ, Amnon, LEVY, Emmanuel. Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties. In: Current opinion in structural biology, 2014, vol. 26, p. 113–120. doi: 10.1016/j.sbi.2014.06.001
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ISSN of the journal0959-440X
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