en
Scientific article
Open access
English

Using transcranial alternating current stimulation to enhance working memory skills in youths with 22q11.2 deletion syndrome : A randomized double-blind sham-controlled study

Published inPsychiatry research, vol. 335, 115835
Publication date2024-05
First online date2024-03-06
Abstract

Abnormal cognitive development, particularly working memory (WM) deficits, is among the first apparent manifestations of psychosis. Yet, cognitive impairment only shows limited response to current pharmacological treatment. Alternative interventions to target cognition are highly needed in individuals at high risk for psychosis, like carriers of 22q11.2 deletion syndrome (22q11.2DS). Here we applied theta-tuned transcranial alternating current stimulation (tACS) between frontal and temporal regions during a visual WM task in 34 deletion carriers. We conducted a double-blind sham-controlled study over three consecutive days. The stimulation parameters were derived from individual structural MRI scan and HD-EEG data acquired at baseline (Day 1) to model current intensity and individual preferential theta peak. Participants were randomized to either sham or tACS (Days 2 and 3) and then completed a visual WM task and a control task. Our findings reveal that tACS was safe and well-tolerated among participants. We found a significantly increased accuracy in the visual WM but not the control task following tACS. Moreover, this enhancement in WM accuracy was greater after tACS than during tACS, indicating stronger offline effects than online effects. Our study therefore supports the application of repeated sessions of brain stimulation in 22q11.2DS.

eng
Keywords
  • 22q11.2 deletion syndrome
  • Cognition
  • Working memory
  • TACS
  • Adolescent
  • Humans
  • Cognition / physiology
  • Cognitive Dysfunction
  • DiGeorge Syndrome / therapy
  • Memory, Short-Term / physiology
  • Transcranial Direct Current Stimulation
  • Double-Blind Method
Citation (ISO format)
LATRECHE, Caren et al. Using transcranial alternating current stimulation to enhance working memory skills in youths with 22q11.2 deletion syndrome : A randomized double-blind sham-controlled study. In: Psychiatry research, 2024, vol. 335, p. 115835. doi: 10.1016/j.psychres.2024.115835
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
ISSN of the journal0165-1781
32views
4downloads

Technical informations

Creation04/22/2024 2:00:15 PM
First validation06/06/2024 12:02:09 PM
Update time06/06/2024 12:02:09 PM
Status update06/06/2024 12:02:09 PM
Last indexation06/06/2024 12:02:16 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack