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Book chapter
English

The Genetics of Murine Hox Loci: TAMERE, STRING, and PANTHERE to Engineer Chromosome Variants

Published inHox genes: methods and protocols, Editors Graba, Yacine & Rezsohazy, René, p. 89-102
PublisherNew York : Springer
Collection
  • Methods in molecular biology; 1196
Publication date2014-07-08
First online date2014-07-08
Abstract

Following their duplications at the base of the vertebrate clade, Hox gene clusters underwent remarkable sub- and neo-functionalization events. Many of these evolutionary innovations can be associated with changes in the transcriptional regulation of their genes, where an intricate relationship between the structure of the gene cluster and the architecture of the surrounding genomic landscape is at play. Here, we report on a portfolio of in vivo genome engineering strategies in mice, which have been used to probe and decipher the genetic and molecular underpinnings of the complex regulatory mechanisms implemented at these loci.

eng
Keywords
  • Mouse genetics
  • Gene regulation
  • In vivo genome engineering
  • TAMERE
  • STRING
  • PANTHERE
Citation (ISO format)
TSCHOPP, Patrick, DUBOULE, Denis. The Genetics of Murine <i>Hox</i> Loci: TAMERE, STRING, and PANTHERE to Engineer Chromosome Variants. In: Hox genes: methods and protocols. New York : Springer, 2014. p. 89–102. (Methods in molecular biology) doi: 10.1007/978-1-4939-1242-1_6
Main files (1)
Book chapter (Published version)
accessLevelRestricted
Identifiers
ISBN1493912429
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