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Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

Published inNature communications, vol. 13, no. 1, p. 1-16; 2929
Errata
  • Erratum in : Horgue LF, Assens A, Fodoulian L, Marconi L, Tuberosa J, Haider A, Boillat M, Carleton A, Rodriguez I. Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity. Nat Commun. 2023 Mar 1;14(1):1156. doi: 10.1038/s41467-023-36849-7.
  • DOI : 10.1038/s41467-023-36849-7
  • PMID : 36859529
Publication date2022-05-25
First online date2022-05-25
Abstract

In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.

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Citation (ISO format)
FLORES HORGUE, Luis et al. Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity. In: Nature communications, 2022, vol. 13, n° 1, p. 1–16. doi: 10.1038/s41467-022-30511-4
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ISSN of the journal2041-1723
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