Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

Article Article scientifique Article Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity eng 2022-05-25 2022-05-25 author Flores Horgue Luis 941114 Département de génétique et évolution (Genev) (BIANI) author Assens Alexis 0000-0002-5194-8980 653599 Département de neurosciences fondamentales (NEUFO) author Fodoulian Leon 0000-0003-4786-5055 800289 Département de génétique et évolution (Genev) (BIANI) author Marconi Archinto Léonardo 840384 Département de génétique et évolution (Genev) (BIANI) author Tuberosa Joël 0000-0001-6022-0556 644501 Département de génétique et évolution (Genev) (BIANI) author Haider Alexander 782699 author Kuby Madlaina 700209 Département de génétique et évolution (Genev) (BIANI) Madlaina Boillat author Carleton Alan 0000-0001-5633-9159 676577 Département de neurosciences fondamentales (NEUFO) author Rodriguez Ivan 0000-0002-6468-0565 28183 Département de génétique et évolution (Genev) (BIANI) 1-16 2929 10.1038/s41467-022-30511-4 35614043 2041-1723 PMC9132991 https://www.nature.com/articles/s41467-022-30511-4 <p>In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.</p> Dewey 616.8 Dewey 590 Swiss National Science Foundation Do context- and output layer-dependent forms of ensemble plasticity exist in the olfactory bulb? 172878 CH Projects Swiss National Science Foundation odorant-induced transcriptional downregulation: from mechanisms to olfactory coding 189153 CH Projects 44 Département de génétique et évolution 162 53 Département de neurosciences fondamentales 21A false 536 Groupe Carleton Alan (neurosciences fondamentales) 876 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185168 https://figshare.com/collections/Transcriptional_adaptation_of_sensory_neurons_to_GPCR_identity_and_activity/5957625 https://github.com/irlabgenev/DREAM_pt2 Nature communications 13 1 0d3617fa-1e27-4bd4-afb3-e3e7a329c575 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 6771906 application/pdf CC BY-4.0 63c6323601823d072f8557c62318ab6237ef499d70b41a7ecdaf6080c893ac22 853a8b5d-cf52-431f-afd9-ded413d6f2a5 Supplemental data Public 41467_2022_30511_MOESM1_ESM.pdf 4073470 application/pdf d85ca68f507790b81dba8dbaa9380fb653b18038f7bec8cb626cf647c8223e29 bd1952f9-0455-4e90-874c-5ffb7fb32489 Supplemental data Public 41467_2022_30511_MOESM2_ESM.pdf 310232 application/pdf 65bd6f176312f711af8562fa4a4ead259d4494056218185a1253504d2d3aabca 497e59d1-e38f-4548-978c-609f3390fd21 Supplemental data Public 41467_2022_30511_MOESM3_ESM.pdf 82896 application/pdf 0597991c85d7ab7b82a9701f1f86bb41e69d8a7a29cf8610d7213a8482f6e225 f52d4673-e675-4a4f-be60-f52d575e5641 Supplemental data Public 41467_2022_30511_MOESM4_ESM.xlsx 69876 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet d2219857b0fc526ec6a293182fe6e117c415e9ec09bb0f199c0d5a42233a1a64 ed5eaf17-2082-4431-bec9-7c86b4285c87 Supplemental data Public 41467_2022_30511_MOESM5_ESM.xlsx 19269 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet e9144ff0e12e2cb74e3ff48ffb2ad2a60ad5863b7e95610675b500963d26cf41 d0307a1a-a376-4414-8aba-77feacc62e75 Supplemental data Public 41467_2022_30511_MOESM6_ESM.xlsx 41420 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet c6e83ef85c8a3a0889f6193c2ba7c3fd74a370f44db0d90bc0e8485de72d8aed 92b36776-a187-40f1-8ab8-05b51d210881 Supplemental data Public 41467_2022_30511_MOESM7_ESM(1).zip 42554288 application/zip 039c2a12f891bac5a980fbeb01d13cb5ee17e9bd6d6ee1d5158cdd95db71586b c81426ee-2ba2-4c71-91fb-9cdef8759bb4 Erratum Public s41467-023-36849-71.pdf 363418 application/pdf adbffc7200661f6034410c94432949353a7cd8d030201f4ca0bfddef2d1e6e0f Erratum in : Horgue LF, Assens A, Fodoulian L, Marconi L, Tuberosa J, Haider A, Boillat M, Carleton A, Rodriguez I. Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity. Nat Commun. 2023 Mar 1;14(1):1156. doi: 10.1038/s41467-023-36849-7. 10.1038/s41467-023-36849-7 36859529 openAccess Faculté des sciences / Section de biologie / Département de génétique et évolution Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity	Nature communications	2022	109	69
DREAM: molecular mechanisms and application to a complex odor		2019	113	0

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Haider, Alexander